天丰素用途
Epibrassinolide 是一种天然油菜素类固醇(BR)衍生物，是一种植物调节剂，具有与哺乳动物类固醇相似的结构。Epibrassinolide在各种癌细胞中是一种潜在的凋亡诱导剂，而不影响非肿瘤细胞生长。
1、产品物理参数：
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常用名
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天丰素
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英文名
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Epibrassinolide
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CAS号
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78821-43-9
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分子量
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480.677
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密度
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1.1±0.1 g/cm3
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沸点
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633.7±55.0 °C at 760 mmHg
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分子式
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C28H48O6
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熔点
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256°C
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闪点
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202.3±25.0 °C
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2、技术资料：
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体外研究
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表油菜素内酯（EBR）是油菜素类固醇，类固醇衍生植物生长调节剂家族的生物活性化合物。将细胞与各种剂量（0-100μM）的表油菜素内酯一起温育24或48小时，并通过MTT测定法测定细胞活力。与LNCaP和DU145前列腺癌细胞中的未处理样品相比，表油菜素内酯以剂量和时间依赖性方式诱导细胞活力丧失。与DU145细胞相比，增加浓度的表油菜素内酯对LNCaP细胞活力丧失更有效，这表明雄**依赖性细胞对表油菜素内酯比对雄**非依赖性前列腺癌细胞更敏感。在进一步的实验中，选择25μM的表油菜素内酯，因为其对两种细胞系具有中等的细胞毒性作用。通过在96小时内计数细胞数来检查表油菜素内酯治-疗对细胞增殖的影响。在LNCaP中观察到比DU145细胞更高和更早的细胞增殖抑制[1]。
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3、天丰素物理化学性质
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密度
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1.1±0.1 g/cm3
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沸点
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633.7±55.0 °C at 760 mmHg
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熔点
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256°C
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分子式
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C28H48O6
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分子量
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480.677
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闪点
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202.3±25.0 °C
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精-确质量
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480.345093
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PSA
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107.22000
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LogP
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3.12
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蒸汽压
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0.0±4.2 mmHg at 25°C
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折射率
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1.536
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储存条件
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−20°C
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4、天丰素英文别名
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CH09964 EPIBRASSINOLIDE
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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1,6-Dioxacyclodeca-3,8-dien
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(1R,3aS,3bS,6aS,8S,9R,10aR,10bS,12aS)-1-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-8,9-dihydroxy-10a,12a-dimethyl-6H-benz[c]indeno[5,4-e]oxepin-6-one
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24-Epicastasterone
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3.24-EPIBRASSINOLIDE
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5R)-3,4-Dihydroxy-5,6-dimethyl-2-heptanyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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(2a,3a,5a,22R,23R,24S)-2,3,22,23-Tetrahydroxy-B-homo-7-oxaergostan-6-one
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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EPI BRASSINOLIDE
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24-EPIBRASSINOLIDE
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2α,3α,22,23-tetrahydroxy-24-methyl-B-homo-7-oxa-5α-cholestan-6-one
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cis,cis-1,6-Dioxa-3,8-cyclodecadien
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1,6-dioxa-cyclodeca-3,8-diene
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4-Epicastasterone
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethyl-2-heptanyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one
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(3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-Dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-on
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(2α,3α,5α,22R,23R,24S)-2,3,22,23-Tetrahydroxy-B-homo-7-oxaergostan-6-one
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2a,3a,22,23-Tetrahydroxy-24-methyl-B-homo-7-oxa-5a-cholestan-6-one
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Epibrassinolide(24-Epibrassinolide)
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Brassinolide(epibrassinolide,Homobrassinolide)
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BRASSINOLIDE(BR)
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2,4-Epibrassinolide
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3H-Benz[c]indeno[5,4-e]oxepin-3-one, 10-[(1S,2R,3R,4S)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-, (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-
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3H-Benz[c]indeno[5,4-e]oxepin-3-one, 10-[(1S,2R,3R,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-5,6-dihydroxy-7a,9a-dimethyl-, (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-
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.(22R,23R,24R)-2
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Brassinolide
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Epibrassinolide
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24-(R)-EPIBRASSINOLIDE
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brassinosteroid
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