产品名称：人可溶性NF-kB激活受体|Human sRANK Receptor
产品规格：
CANSPEC品质提供的人可溶性NF-kB激活受体|Human sRANK Receptor性能**，中文名称为人可溶性NF-kB激活受体|Human sRANK Receptor。
产品人可溶性NF-kB激活受体|Human sRANK Receptor以其优良的品质满足您不同实验的多种需求。并保证每批人可溶性NF-kB激活受体|Human sRANK Receptor的质量和品质优良。欢迎来电洽谈选购，更多产品请登录www.canspecsci.com
Synonyms :
TNFRSF11A, ODFR (osteoclast differentiation factor receptor), ODAR (osteoclast differentiation and activation receptor), TRANCE Receptor
Description :
RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).
Catalog #:
310-08
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted sRANK Receptor is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
Determined by its ability to suppress the production of IFN-gamma from human PBMCs.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK
PubMed Link :
RANK+AND+Receptor+AND+TNF
Country of Origin :
USA
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