产品名称：Recombinant Human Heregulin-β1 (HRG1-β)
产品规格： C02-100-03-100ugHuman Heregulin beta-1100ug￥4,900C02-100-03-10ugHuman Heregulin beta-110ug￥680C02-100-03-1mgHuman Heregulin beta-11mg￥21,000C02-100-03-500ugHuman Heregulin beta-1500ug￥12,600C02-100-03-50ugHuman Heregulin beta-150ug￥1,960
单 位：瓶
关 键 字：Human Heregulin beta-1|Human Heregulin
CANSPEC品质提供的Human Heregulin beta-1性能**，英文名称Human Heregulin beta-1，简称为Human Heregulin beta-1，中文名称为Human Heregulin beta-1。
产品Human Heregulin beta-1以其优良的品质满足您不同实验的多种需求。并保证每批Human Heregulin beta-1的质量和Human Heregulin beta-1品质优良。English InformationSynonyms :Neuregulin1 (NRG1-β1), Neu differentiation factor (rat)Description :Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-β1 (HRG1-β1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β1 (65 amino acid residues).Catalog #:100-03Source :E.coliStability :The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted Heregulin-β 1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.Purity :Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin Level :Endotoxin level is less than 0.1 ng per μg (1EU/μg).Biological Activity :The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.Selected References :Selected List of References Citing This PeproTech ProductAA Sequence :SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE PubMed Link :Heregulin-beta1Country of Origin :USA
Synonyms :
Neuregulin1 (NRG1-β1), Neu differentiation factor (rat)
Description :
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant human Heregulin-β1 (HRG1-β1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β1 (65 amino acid residues).
Catalog #:
100-03
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted Heregulin-β 1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
PubMed Link :
Heregulin-beta1
Country of Origin :
USA
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