产品名称：人血浆可溶性CD40配体/抗酒石酸酸性磷酸酶|Human sCD-40 Ligand/TRAP
产品规格：
单 位：支
关 键 字：人血浆可溶性CD40配体/抗酒石酸酸性磷酸酶|Human sCD-40 Ligand/TRAP
CANSPEC品质提供的人血浆可溶性CD40配体/抗酒石酸酸性磷酸酶|Human sCD-40 Ligand/TRAP性能**，英文名称Human sCD-40 Ligand/TRAP，中文名称为人血浆可溶性CD40配体/抗酒石酸酸性磷酸酶。
产品人血浆可溶性CD40配体/抗酒石酸酸性磷酸酶|Human sCD-40 Ligand/TRAP以其优良的品质满足您不同实验的多种需求。并保证每批的质量和品质优良。
Synonyms :
soluble CD40 Ligand, TNFSF5, TRAP, CD154, gp39, T-BAM
Description :
CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L. Recombinant human soluble CD40 ligand is a 16.3 kDa protein containing 149 amino acid residues comprising the receptor binding TNF-like domain of CD40L.
Catalog #:
310-02
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted sCD40L is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
Assay #1: Determined by the stimulation of IL-12 induction by human PBMCs. Assay #2: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The expected ED50 for this effect is 5-10 ng/ml. Note: Results may vary with PBMC donors.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
MQKGDQNPQI AAHVISEASS KTTSVLQWAE KGYYTMSNNL VTLENGKQLT VKRQGLYYIY AQVTFCSNRE ASSQAPFIAS LWLKSPGRFE RILLRAANTH SSAKPCGQQS IHLGGVFELQ PGASVFVNVT DPSQVSHGTG FTSFGLLKL
PubMed Link :
CD40+AND+ligand
Country of Origin :
USA
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