人三叶因子2|Human TFF2 (TreFoil 2)

Synonyms :

Trefoil Factor 2, Spasmolytic polypeptide (SP), Spasmolysin

Description :

The Trefoil Factor peptides (TFF1, TFF2 and TFF3) are expressed in the gastrointestinal tract, and appear to play an important role in intestinal mucosal defense and repair. TFF2 has been shown to inhibit gastrointestinal motility and gastric acid secretion. Recent data suggests a potential role for TFF2 in acute and chronic asthma (Nikolaidis, N.M. et al. Am. Journal Respir. Cell Mol. Biol. (2003) 4: 458-464). Recombinant human TFF2 is a 12.0 kDa polypeptide of 106 amino acid residues, which includes a 40-amino acid trefoil motif containing three conserved intramolecular disulfide bonds.

Catalog #:

300-59

Source :

E.coli

Stability :

The lyophilized protein is stable for at least 2 years from date of receipt at -20⁰C. Reconstituted TFF2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20⁰C. Avoid repeated freeze/thaw cycles.

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per µg (1EU/µg).

Biological Activity :

Assay #1: Determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 µg/ml.

Assay #2: Determined by its ability to chemoattract human MCF-7 cells using a concentration range of 1.0-10.0 ng/ml.

Selected References :

Selected List of References Citing This PeproTech Product

AA Sequence :

EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSV TGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECAS RKCCFSNFIF EVPWCFFPKS VEDCHY

PubMed Link :

TFF-2+OR+TFF2

Country of Origin :

USA