产品名称：人白细胞介素-6受体|Human IL-6 Receptor
产品规格：
单 位：瓶
关 键 字：人白细胞介素-6受体|Human IL-6 Receptor
CANSPEC品质提供的人白细胞介素-6受体|Human IL-6 Receptor性能**，英文名称人白细胞介素-6受体|Human IL-6 Receptor，简称为人白细胞介素-6受体|Human IL-6 Receptor，中文名称为人白细胞介素-6受体|Human IL-6 Receptor。
产品 人白细胞介素-6受体|Human IL-6 Receptor以其优良的品质满足您不同实验的多种需求。并保证每批人白细胞介素-6受体|Human IL-6 Receptor的质量和人白细胞介素-6受体|Human IL-6 Receptor品质优良。
Synonyms :
soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
Description :
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R α and gp130. The IL-6R α chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R α. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R α alone. IL-6R α is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6R α which consists of only the extracellular domain of the IL-6R α chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6R α is a 37.6 kDa protein consisting of the extracellular domain of the IL-6R α chain (338 amino acid residues).
Catalog #:
200-06R
Source :
HEK 293 cells
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted sIL-6R α is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
The ED50 was determined by it's ability to intensify the IL-6 induced growth inhibition of murine M1 cells is ≤ 5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH ASGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPAPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD
PubMed Link :
IL-6+AND+receptor-alpha
Country of Origin :
USA
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