产品名称：人类分化因子-II|Human GDF-II
产品规格：
单 位：瓶
关 键 字：人类分化因子-II|Human GDF-II
CANSPEC品质提供的人类分化因子-II|Human GDF-II性能**，英文名称人类分化因子-II|Human GDF-II，简称为人类分化因子-II|Human GDF-II，中文名称为人类分化因子-II|Human GDF-II。
产品人类分化因子-II|Human GDF-II以其优良的品质满足您不同实验的多种需求。并保证每批人类分化因子-II|Human GDF-II的质量和人类分化因子-II|Human GDF-II品质优良。English InformationSynonyms :Growth/Differentiation Factor-11, BMP-11Description :GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.Catalog #:120-11Source :E.coliStability :The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted GDF-11 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.Purity :Greater than 98% by SDS-PAGE gel and HPLC analyses.Endotoxin Level :Endotoxin level is less than 0.1 ng per µg (1EU/µg).Biological Activity :The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 µg/ml.AA Sequence :NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS PubMed Link :GDF+AND+11Country of Origin :USA
Synonyms :
Growth/Differentiation Factor-11, BMP-11
Description :
GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell-cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8 sharing 90% amino-acid sequence identity.
Catalog #:
120-11
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted GDF-11 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
The ED50 was determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 µg/ml.
AA Sequence :
NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
PubMed Link :
GDF+AND+11
Country of Origin :
USA
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