产品名称:骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer
产品规格:
单 位:瓶
关 键 字:骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer
CANSPEC品质提供的骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer性能**,英文名称骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer,简称为骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer,中文名称为骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer。
产品骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer以其优良的品质满足您不同实验的多种需求。并保证每批 的质量和骨形态生成蛋白-4(BMP-4)拮抗剂Noggin二聚体|Human NOGGIN-Dimer品质优良。English Information
Synonyms :
none.
Description :
Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46.2 kDa disulfide-linked homodimer (120-10D) consisting of two 206 amino acid polypeptide chains.
Catalog #:
120-10D
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted Noggin is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected The ED50 for this effect is 0.01-0.02 μg/ml of Noggin.
AA Sequence :
MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
PubMed Link :
Noggin
Country of Origin :
USA
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