产品名称:人内脂素|内脏脂肪素|Human Visfatin
产品规格:
单 位:瓶
关 键 字:人内脂素|内脏脂肪素|Human Visfatin
CANSPEC品质提供的人内脂素|内脏脂肪素|Human Visfatin性能**,英文名称人内脂素|内脏脂肪素|Human Visfatin,简称为人内脂素|内脏脂肪素|Human Visfatin,中文名称为人内脂素|内脏脂肪素|Human Visfatin。
产品人内脂素|内脏脂肪素|Human Visfatin以其优良的品质满足您不同实验的多种需求。并保证每批人内脂素|内脏脂肪素|Human Visfatin的质量和人内脂素|内脏脂肪素|Human Visfatin品质优良。
Synonyms :
PBEF (Pre-B cell colony-enhancing factor)
Description :
Visfatin is a 55 kDa protein produced and secreted primarily by white adipose tissue. Recently, Visfatin was isolated from visceral fat deposits and shown to possess insulin-mimetic activity. Like insulin, Visfatin exerts hypoglycemic effects by interacting with the insulin receptor. The binding affinity of Visfatin for the insulin receptor is similar to that of insulin, but it does not compete with insulin, suggesting that the two proteins interact with different receptor sites. The circulating levels of Visfatin are much lower than those of insulin and are not affected by feeding, implying that the hypoglycemic effect of Visfatin may not be of physiological importance. The plasma Visfatin levels, like those of Leptin, correlate positively with the percent of body fat and increase during the development of obesity. Another similarity between Visfatin and Leptin is that their amino acid sequence is highly conserved across different mammalian species and shows no homology to any known protein. Receptors for both Leptin (Ob-R) and Visfatin (i.e. the insulin receptor) are expressed by neurons within the arcuate nucleus of the hypothalamus, a brain area that plays a pivotal role in the regulation of energy metabolism. Although the metabolic function of Visfatin is still unknown, it appears that this newly identified adipocytokine might play an important role, similar to that of Leptin, in the regulation of body weight, i.e. as an afferent signal reflecting excess body fat. Recombinant human Visfatin is a 52.5 kDa protein containing 465 amino acid residues (isoform 1).
Catalog #:
130-09
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted Visfatin is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED50was determined by the dose-dependant proliferation of the RPMI 8226 cells. The expected ED50for this effect is 15.0-20.0 ng/ml.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
MPPNTSKVYS YFECREKKTE NSKLRKVKYE ETVFYGLQYI LNKYLKGKVV TKEKIQEAKD VYKEHFQDDV FNEKGWNYIL EKYDGHLPIE IKAVPEGFVI PRGNVLFTVE NTDPECYWLT NWIETILVQS WYPITVATNS REQKKILAKY LLETSGNLDG LEYKLHDFGY RGVSSQETAG IGASAHLVNF KGTDTVAGLA LIKKYYGTKD PVPGYSVPAA EHSTITAWGK DHEKDAFEHI VTQFSSVPVS VVSDSYDIYN ACEKIWGEDL RHLIVSRSTQ APLIIRPDSG NPLDTVLKVL EILGKKFPVT ENSKGYKLLP PYLRVIQGDG VDINTLQEIV EGMKQKMWSI ENIAFGSGGG LLQKLTRDLL NCSFKCSYVV TNGLGINVFK DPVADPNKRS KKGRLSLHRT PAGNFVTLEE GKGDLEEYGQ DLLHTVFKNG KVTKSYSFDE IRKNAQLNIE LEAAHH
PubMed Link :
Visfatin
Country of Origin :
USA
国内免费服务专线:400 608 7598(据说天才可以在15秒内记住我们的免费电话哦^_^)
服务升级,全新企业QQ为您服务,企业QQ号:4006087598
创赛官网升级为创赛优选商城,请移步www.canspec.cn注册登录,新用户注册送1000元现金券
沪公网安备 31011402005168号