产品名称:人类黑色素瘤活性抑制因子|Human MIA
产品规格:
单 位:瓶
关 键 字:人类黑色素瘤活性抑制因子|Human MIA
CANSPEC品质提供的 人类黑色素瘤活性抑制因子|Human MIA性能**,英文名称 人类黑色素瘤活性抑制因子|Human MIA,简称为人类黑色素瘤活性抑制因子|Human MIA,中文名称为人类黑色素瘤活性抑制因子|Human MIA。
产品人类黑色素瘤活性抑制因子|Human MIA以其优良的品质满足您不同实验的多种需求。并保证每批 人类黑色素瘤活性抑制因子|Human MIA的质量和人类黑色素瘤活性抑制因子|Human MIA品质优良。
Synonyms :
Melanoma Inhibitory Activity, Cartilage-derived retinoic acid-sensitive protein (CD-RAP)
Description :
MIA is the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family; MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells that promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis. Recombinant human MIA is a 12.2 kDa globular protein containing 108 amino acid residues including two intramolecular disulfide bonds.
Catalog #:
130-01
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted MIA is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED50 was determined by the dose-dependant proliferation of the human A375 melanoma cell line. The expected ED50 for this effect is 4-6 μg/ml.
AA Sequence :
MGPMPKLADR KLCADQECSH PISMAVALQD YMAPDCRFLT IHRGQVVYVF SKLKGRGRLF WGGSVQGDYY GDLAARLGYF PSSIVREDQT LKPGKVDVKT DKWDFYCQ
PubMed Link :
MIA+AND+Melanoma+Inhibitory+Activity
Country of Origin :
USA
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