产品名称:人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1
产品规格:
单 位:瓶
关 键 字:人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1
CANSPEC品质提供的人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1性能**,英文名称人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1,简称为人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1,中文名称为人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1 。
产品人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1以其优良的品质满足您不同实验的多种需求。并保证每批人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1的质量和人分化因子-15/巨噬细胞抑制因子-1|Human GDF-15/MIC-1品质优良。
Synonyms :
MIC-1, Placental TGFβ, Prostate differentiation factor
Description :
GDF-15 belongs to the TGF-β cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in placenta and to a much lesser extent in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest a role for GDF-15 in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers. Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 114 amino-acid polypeptide chains.
Catalog #:
120-28
Source :
cell culture
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted GDF-15/MIC-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
Determined by a cell inhibition assay using DU-145 cells. The expected ED50 for this effect is 1.0-2.0 μg/ml.
AA Sequence :
ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI
PubMed Link :
GDF-15+AND+MIC-1
Country of Origin :
USA
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