产品名称:人富半胱氨酸肝素结合蛋白61|Human CYR61
产品规格:
单 位:瓶
关 键 字:人富半胱氨酸肝素结合蛋白61|Human CYR61
CANSPEC品质提供的人富半胱氨酸肝素结合蛋白61|Human CYR61性能**,英文名称人富半胱氨酸肝素结合蛋白61|Human CYR61,简称为人富半胱氨酸肝素结合蛋白61|Human CYR61,中文名称为人富半胱氨酸肝素结合蛋白61|Human CYR61。
产品人富半胱氨酸肝素结合蛋白61|Human CYR61以其优良的品质满足您不同实验的多种需求。并保证每批人富半胱氨酸肝素结合蛋白61|Human CYR61的质量和人富半胱氨酸肝素结合蛋白61|Human CYR61品质优良。
Synonyms :
CCN1, GIGI protein
Description :
CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).
Catalog #:
120-25
Source :
E.coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted CYR61 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml.
AA Sequence :
MTCPAACHCP LEAPKCAPGV GLVRDGCGCC KVCAKQLNED CSKTQPCDHT KGLECNFGAS STALKGICRA QSEGRPCEYN SRIYQNGESF QPNCKHQCTC IDGAVGCIPL CPQELSLPNL GCPNPRLVKV TGQCCEEWVC DEDSIKDPME DQDGLLGKEL GFDASEVELT RNNELIAVGK GSSLKRLPVF GMEPRILYNP LQGQKCIVQT TSWSQCSKTC GTGISTRVTN DNPECRLVKE TRICEVRPCG QPVYSSLKKG KKCSKTKKSP EPVRFTYAGC LSVKKYRPKY CGSCVDGRCC TPQLTRTVKM RFRCEDGETF SKNVMMIQSC KCNYNCPHAN EAAFPFYRLF NDIHKFRD
PubMed Link :
CYR61
Country of Origin :
USA
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