产品名称:人肿瘤生长因子β2|Human TGF-beta2
产品规格:
单 位:瓶
关 键 字:人肿瘤生长因子β2|Human TGF-beta2
CANSPEC品质提供的人肿瘤生长因子β2|Human TGF-beta2性能**,英文名称人肿瘤生长因子β2|Human TGF-beta2,简称为人肿瘤生长因子β2|Human TGF-beta2,中文名称为人肿瘤生长因子β2|Human TGF-beta2 。
产品人肿瘤生长因子β2|Human TGF-beta2以其优良的品质满足您不同实验的多种需求。并保证每批人肿瘤生长因子β2|Human TGF-beta2的质量和人肿瘤生长因子β2|Human TGF-beta2品质优良。
Synonyms :
Transforming Growth Factor-beta2, Glioblastoma-derived T cell suppressor factor, BSC-1, Cetermin, Polyergin
Description :
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.* Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
Catalog #:
100-35
Source :
(BTI-Tn-5B1-4) High-5 Insect Cells*/i>
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted TGF-β2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS
PubMed Link :
TGF+AND+beta+AND+2
Country of Origin :
USA
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