产品名称:人肝素结合性表皮生长因子|Human HB-EGF
产品规格:
单 位:瓶
关 键 字:人肝素结合性表皮生长因子|Human HB-EGF
CANSPEC品质提供的人肝素结合性表皮生长因子|Human HB-EGF性能**,英文名称人肝素结合性表皮生长因子|Human HB-EGF,简称为人肝素结合性表皮生长因子|Human HB-EGF,中文名称为人肝素结合性表皮生长因子|Human HB-EGF。
产品人肝素结合性表皮生长因子|Human HB-EGF以其优良的品质满足您不同实验的多种需求。并保证每批 人肝素结合性表皮生长因子|Human HB-EGF的质量和人肝素结合性表皮生长因子|Human HB-EGF品质优良。English Information
Synonyms :
Heparin Binding EGF-like growth factor, HBEGF, Diphteria toxin receptor, DTR
Description :
HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extra-cellular EGF-like and heparin binding domains of the full length HB-EGF protein.
Catalog #:
100-47
Source :
E. coli
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted HB-EGF is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 95% by SDS-PAGE gel and HPLC analyses
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
DLQEADLDLL RVTLSSKPQA LATPNKEEHG KRKKKGKGLG KKRDPCLRKY KDFCIHGECK YVKELRAPS CICHPGYHGE RCHGLSL
PubMed Link :
HB-EGF
Country of Origin :
USA
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