产品名称:人肿瘤生长因子β3|Human TGF-beta3
产品规格:2ug
单 位:瓶
关 键 字:人肿瘤生长因子β3|Human TGF-beta3
CANSPEC品质提供的人肿瘤生长因子β3|Human TGF-beta3性能**,英文名称人肿瘤生长因子β3|Human TGF-beta3,简称为人肿瘤生长因子β3|Human TGF-beta3,中文名称为人肿瘤生长因子β3|Human TGF-beta3。
产品人肿瘤生长因子β3|Human TGF-beta3以其优良的品质满足您不同实验的多种需求。并保证每批人肿瘤生长因子β3|Human TGF-beta3 的质量和人肿瘤生长因子β3|Human TGF-beta3品质优良。
Synonyms :
Transforming Growth Factor-beta3
Description :
The three mammalian forms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation, and motility as well as syntehsis and deposition of the extracellular matrix. They are involved in various physiological processes incliding embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-β3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes. Recombinant TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Catalog #:
100-36
Source :
Sf-9 cells
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted TGF-β3 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED50 was found to be ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
PubMed Link :
TGF+AND+beta+AND+3
Country of Origin :
USA
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