产品名称:人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO
产品规格:
单 位:瓶
关 键 字:人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO
CANSPEC品质提供的人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO性能**,英文名称人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO,简称为人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO,中文名称为人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO。
产品人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO以其优良的品质满足您不同实验的多种需求。并保证每批人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO的质量和人类转化生长因子-β1(胆固醇氧化酶)|Human TGF-beta1-Produced in CHO品质优良。Synonyms :Transforming Growth Factor-beta1, Differentiation inhibiting factor, Cartilage-inducing factorDescription :The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Recombinant human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.Catalog #:100-21CSource :CHO cells* *Made using a license from PHS, NIH. Patent Pending.Stability :The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted TGF-β1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.Purity :Greater than 98% by SDS-PAGE gel and HPLC analysesEndotoxin Level :Endotoxin level is less than 0.1 ng per μg (1EU/μg).Biological Activity :The ED50 was determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mgSelected References :Selected List of References Citing This PeproTech ProductAA Sequence :ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS PubMed Link :TGF+AND+beta+AND+1Country of Origin :USA
Synonyms :
Transforming Growth Factor-beta1, Differentiation inhibiting factor, Cartilage-inducing factor
Description :
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Recombinant human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Catalog #:
100-21C
Source :
CHO cells* *Made using a license from PHS, NIH. Patent Pending.
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted TGF-β1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses
Endotoxin Level :
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
Biological Activity :
The ED50 was determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
PubMed Link :
TGF+AND+beta+AND+1
Country of Origin :
USA
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