产品名称:人类转化生长因子-β1(哺乳动物源性)|Human TGF-beta1-Mammalian
产品规格:
单 位:瓶
关 键 字:人类转化生长因子-β1(哺乳动物源性)|Human TGF-beta1-Mammalian
CANSPEC品质提供的人类转化生长因子-β1(哺乳动物源性)|Human TGF-beta1-Mammalian性能**,英文名称人类转化生长因子-β1(哺乳动物源性)|Human TGF-beta1-Mammalian,简称为人类转化生长因子-β1(哺乳动物源性)|Human TGF-beta1-Mammalian。
产品人类转化生长因子-β1(哺乳动物源性)|Human TGF-beta1-Mammalian以其优良的品质满足您不同实验的多种需求。并保证每批人类转化生长因子-β1(哺乳动物源性)|Human TGF-beta1-Mammalian的质量和品质优良。
Synonyms :
Transforming Growth Factor-beta1, Differentiation inhibiting factor, Cartilage-inducing factor
Description :
The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Human TGF-β1 is a 25.0 kDa protein with each subunit containing 112 amino acid residues, linked by a single disulfide bond.
Catalog #:
100-21
Source :
A293 cells
Stability :
The lyophilized protein is stable for at least 2 years from date of receipt at -200C. Reconstituted TGF-β1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -200C. Avoid repeated freeze/thaw cycles.
Purity :
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin Level :
Endotoxin level is less than 0.1 ng per µg (1EU/µg).
Biological Activity :
The ED50 was determined by TGF-beta1's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Selected References :
Selected List of References Citing This PeproTech Product
AA Sequence :
ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS
PubMed Link :
TGF+AND+beta+AND+1
Country of Origin :
USA
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