IGFBP4蛋白产品信息 产品名称:重组小鼠 IGFBP4 蛋白|Mouse Insulin-like Growth Factor Binding Protein 4 Protein|厂家现货 IGFBP4 别名: Igfbp4 , RP23-333D2.6, AI875747, Deb2, IGFBP-4 表达方式: A DNA sequence encoding the extracellular domain ( Met 1 - Glu 254 ) of mouse IGFBP4 ( NP_034647.1 ) precursor was expressed with a C-terminal polyhistidine tag. 种属: Mouse 表达宿主: Human Cells IGFBP4蛋白质控指标 纯度: > 95 % as determined by SDS-PAGE SDS-PAGE 生物活性:Measured in a serumfree cell proliferation assay using MCF7 human breast adenocarcinoma cells. ( Karey, K.P. et al. 1988, Cancer Research 48: 4083. ) The ED50 for this effect is typically 0.1-0.6 μg/mL 内**: < 1.0 EU per μg of the protein as determined by the LAL method. 稳定性: Samples are stable for up to twelve months from date of receipt at -70℃ 预测N端: Asp 22 分子量: The secreted recombinant mouse IGFBP4 consists of 244 amino acids and has a calculated molecular mass of 27.2 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 38 kDa protein in SDS-PAGE under reducing conditions. 缓冲液: Lyophilized from sterile PBS , pH 7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. IGFBP4蛋白使用指南 储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. IGFBP4蛋白背景综述 Mouse insulin-like growth factor binding protein 4 (IGFBP4), is one of the six Insulin-like growth factor-binding proteins (IGFBPs) , that control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and 2 through high-affinity IGFBP/IGF interactions. Despite their structural similarity,each IGFBPs has unique properties and exhibits specific functions. IGFBP4 has an IGFBP domain and a thyroglobulin type-I domain. It binds IGFs and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. It is suggested that IGFBP4 is a unique protein in that it consistently inhibits several cancer cells in vivo and in vitro through a mechanism dependent or independent of IGFs. Overexpression of IGFBP4 in transgenic animal models causes reduced growth of organs containing smooth muscle. 参考文献 Zhou, R. et al., 2004 , J Mol Endocrinol .32 (2): 349-364. Sitar,T. et al., 2006, Proc Natl Acad Sci USA. 103 (35): 13028-13033. Durai, R. et al., 2007, World Journal of Surgical Oncology. 5: 128. 包装:5ug 20ug
1、产品质量问题,在产品售出7日内提出异议并且产品未有损坏,试剂类产品,需要提供详细的检测数据,创赛负责免费退换货服务; 2、本产品属于消耗品,不提供质保服务; 3、所有产品售后问题,请直接联系我司,我们将会尽快为您响应处理 查询关键词:重组小鼠 IGFBP4 蛋白,Mouse Insulin-like Growth Factor Binding Protein 4 Protein,厂家现货,原料药,大包装定制,现货促销,医药中间体,科学仪器,实验室耗材,生化试剂,创赛中国,细胞因子 CANSPEC品质提供的重组小鼠 IGFBP4 蛋白|Mouse Insulin-like Growth Factor Binding Protein 4 Protein|厂家现货性能**,其优良的品质满足您不同实验的多种需求。 本产品由上海创赛品质提供,欢迎咨询国内免费服务专线:400-608-7598,更多产品信息请登录www.canspecsci.com或www.4006087598.com
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