重组人 IGF2BP2 / IMP2 / p62 蛋白|IGF2BP2 / IMP2 Protein |技术资料|参数

IGF2BP2 / IMP2蛋白产品信息
产品名称：重组人 IGF2BP2 / IMP2 / p62 蛋白|IGF2BP2 / IMP2 Protein |技术资料|参数
别名: IMP-2,  IMP2,  VICKZ2,  p62
表达方式: A DNA sequence encoding the human IGF2BP2 isoform 1 ( Q9Y6M1-2 ) ( Met 1 - Lys 599 ) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus
种属: Human
表达宿主: Baculovirus
IGF2BP2 / IMP2蛋白质控指标
纯度: > 76 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human IGF2BP2/GST chimera consists of 836 amino acids and has a calculated molecular mass of 94 kDa. It migrates as an approximately 90 kDa band in SDS-PAGE under reducing conditions
缓冲液: Lyophilized from sterile 50mM Tris, 500mM NaCl, 0.5mM PMSF, 5mM Reduced Glutathione, pH 8.0
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IGF2BP2 / IMP2蛋白使用指南
储存方法:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IGF2BP2 / IMP2蛋白背景综述
Insulin-like growth factor 2 mRNA-binding protein 2, also known as IGF2 mRNA-binding protein 2, Hepatocellular carcinoma autoantigen p62, IGF-II mRNA-binding protein 2, VICKZ family member 2, IGF2BP2 and IMP2, is a cytoplasm protein which belongs to the RRM IMP/VICKZ family. IGF2BP2 / IMP2 is expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). It is also expressed in testicular cancer (at protein level). It is expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. IGF2BP2 / IMP2 binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. This binding is isoform-specific. IGF2BP2 / IMP2 may regulate translation of target mRNAs. Genetic variation at the IGF2BP2 gene has been associated with type 2 diabetes (T2D) by genome-wide association studies and by replication analyses. 
参考文献
Zhang JY, et al.,1999, J Exp Med. 189 (7): 1101-10.
Nielsen J, et al., 1999, Mol Cell Biol. 19 (2): 1262-70.
Huang,Q. et al., 2010, Acta Pharmacol Sin. 31 (6):709-17.
Rodriguez,S. et al., 2010, Growth Horm IGF Res. 20 (4):310-8.

包装：20ug

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