IGFBP6 / IBP-6蛋白产品信息
别名: IGFBP-6 表达方式: 重组小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|产品详情|现货 A DNA sequence encoding the mouse IGFBP6 ( NP_032370.2 ) ( Met 1 -Gly 238 ) was expressed, with a polyhistidine tag at the C-terminus 种属: Mouse 表达宿主: Human Cells IGFBP6 / IBP-6蛋白质控指标 产品名称: 纯度: > 92 % as determined by SDS-PAGE SDS-PAGE 内**: < 1.0 EU per μg of the protein as determined by the LAL method 稳定性: Samples are stable for up to twelve months from date of receipt at -70℃ 预测N端: Gln 20 分子量: The recombinant mouse IGFBP6 consists of 224 amino acids and has a predicted molecular mass of 24 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmIGFBP6 is approximately 30 kDa due to glycosylation 缓冲液: Lyophilized from sterile PBS , pH 7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. IGFBP6 / IBP-6蛋白使用指南 储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. IGFBP6 / IBP-6蛋白背景综述 Mouse insulin-like growth factor-binding protein 6, also known as IGF-binding protein 6, IGFBP-6 and IBP-6, is a secreted protein which contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. The insulin-like growth factor (IGF) axis is a complex system composed of two mitogenic ligands, IGF-I and IGF-II, two receptors, IGF-IR and IGF-IIR, and six binding proteins, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6. IGF-binding proteins ( IGFBPs ) prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. Increased IGFBP6 / IBP6 expression in oral tumors could be regarded as a potential predictive marker of tumor sensitivity and could be used for prognostic purposes, since a significant correlation could be observed between increased induction of apoptotic cell death and elevated levels of IGFBP6 / IBP6 in these tumors. 参考文献 Saito,T. et al., 2003, Zoolog Sci. 20 (4):441-7. Kamangar,B.B. et al., 2006, Endocrinology. 147 (5):2399-410. Shynlova,O. et al., 2007, Biol Reprod. 76 (4):571-8. Zhang,L. et al., 2007, Dig Dis Sci. 52 (1):248-53. Cacalano,N.A. et al., 2008, Apoptosis. 13 (12):1439-49. 包装:5ug 20ug
1、产品质量问题,在产品售出7日内提出异议并且产品未有损坏,试剂类产品,需要提供详细的检测数据,创赛负责免费退换货服务; 2、本产品属于消耗品,不提供质保服务; 3、所有产品售后问题,请直接联系我司,我们将会尽快为您响应处理 查询关键词:重组小鼠 IGFBP6 / IBP-6 蛋白,IGFBP6 / IBP-6 Protein,产品详情,现货,原料药,大包装定制,现货促销,医药中间体,科学仪器,实验室耗材,生化试剂,创赛中国,细胞因子 CANSPEC品质提供的重组小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|产品详情|现货性能**,其优良的品质满足您不同实验的多种需求。 本产品由上海创赛品质提供,欢迎咨询国内免费服务专线:400-608-7598,更多产品信息请登录www.canspecsci.com或www.4006087598.com
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