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重组小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|产品详情|现货

产品名称: 重组小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|产品详情|现货
产品型号: C86-504-60
产品展商: 博飞美科
产品文档: 无相关文档

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重组小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|产品详情|现货由上海创赛科学仪器有限公司品质提供。上海创赛科学仪器有限公司是专业**试剂生产及供应商,其优良的品质满足您不同实验的多种需求,欢迎拨打4006087598洽谈选购,更多产品详情请登录www.canspecsci.com


重组小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|产品详情|现货  的详细介绍

IGFBP6 / IBP-6蛋白产品信息

别名: 
IGFBP-6
表达方式: 重组小鼠 IGFBP6 / IBP-6 蛋白|IGFBP6 / IBP-6 Protein|产品详情|现货
A DNA sequence encoding the mouse IGFBP6 ( NP_032370.2 ) ( Met 1 -Gly 238 ) was expressed, with a polyhistidine tag at the C-terminus
种属: Mouse
表达宿主: Human Cells
IGFBP6 / IBP-6蛋白质控指标
产品名称:
纯度: > 92 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 20
分子量: The recombinant mouse IGFBP6 consists of 224 amino acids and has a predicted molecular mass of 24 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmIGFBP6 is approximately 30 kDa due to glycosylation
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

IGFBP6 / IBP-6蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
IGFBP6 / IBP-6蛋白背景综述
Mouse insulin-like growth factor-binding protein 6, also known as IGF-binding protein 6, IGFBP-6 and IBP-6, is a secreted protein which contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. The insulin-like growth factor (IGF) axis is a complex system composed of two mitogenic ligands, IGF-I and IGF-II, two receptors, IGF-IR and IGF-IIR, and six binding proteins, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP5, IGFBP6. IGF-binding proteins ( IGFBPs ) prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.The IGFBPs exert their actions through their regulation of IGF bioavailability for IGF receptors. Increased IGFBP6 / IBP6 expression in oral tumors could be regarded as a potential predictive marker of tumor sensitivity and could be used for prognostic purposes, since a significant correlation could be observed between increased induction of apoptotic cell death and elevated levels of IGFBP6 / IBP6 in these tumors.
参考文献
Saito,T. et al., 2003, Zoolog Sci. 20 (4):441-7.
Kamangar,B.B. et al., 2006, Endocrinology. 147 (5):2399-410.
Shynlova,O. et al., 2007, Biol Reprod. 76 (4):571-8.
Zhang,L. et al., 2007, Dig Dis Sci. 52 (1):248-53.
Cacalano,N.A. et al., 2008, Apoptosis. 13 (12):1439-49.

包装:5ug  20ug

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