重组人 IGFBP7 / IBP-7 蛋白|Insulin-like growth factor binding protein 7 Protein|技术资料

IGFBP7 / IBP-7蛋白产品信息
产品名称:重组人 IGFBP7 / IBP-7 蛋白|Insulin-like growth factor binding protein 7 Protein|技术资料
别名: AGM, FSTL2, IBP-7, IGFBP-7, IGFBP-7v, IGFBPRP1, MAC25, PSF, TAF
表达方式: A DNA sequence encoding the human IGFBP7 (Q16270) (Asp 30- Leu 282) was fused with a polyhistidine tag at the N-terminus.
种属: Human
表达宿主: Human Cells

IGFBP7 / IBP-7蛋白质控指标
纯度: >92 % as determined by SDS-PAGE.  SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 27
分子量: The secreted recombinant human IGFBP7 comprises 273 amino acids and has a predicted molecular mass of 28.6 kDa. ?The apparent molecular mass of rhIGFBP7 is approximately 36 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IGFBP7 / IBP-7蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IGFBP7 / IBP-7蛋白背景综述
Insulin-like growth factor-binding protein 7, also known as IGF-binding protein 7, IBP-7, IGFBP-7, IGFBP-rP1, MAC25 protein, PGI2-stimulating factor, Prostacyclin-stimulating factor, Tumor-derived adhesion factor TAF and IGFBP7, is a secreted protein involved in several cellular processes, including proliferation, senescence and apoptosis. Loss of IGFBP7 expression is a critical step in the development of human tumors, including melanoma and colon cancer. IGFBP7 contains one Ig-like C2-type (immunoglobulin-like) domain, one IGFBP N-terminal domain and one Kazal-like domain. IGFBP7 binds IGF-I and IGF-II with a relatively low affinity. IGFBP7 stimulates prostacyclin (PGI2) production. It also stimulates cell adhesion. The major function of the IGFBP7 protein is in the regulation of availability of Insulin like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. IGFBP7 binds to IGF with high affinity. It also stimulates cell adhesion. IGFBP7 protein is implicated in some cancers.
参考文献
Akaogi K. et al.,1994, Biochem Biophys Res Commun. 198: 1046-53.
Oh Y. et al., 1996, J Biol Chem. 271: 30322-30325.
Wilson EM. et al., 2001, J Clin Endocrinol Metab. 86: 4504-4511.
Sanjida Ahmed., et al., 2006, FEBS Journal.273 (3): 615-27.
Gommans WM., et al., 2008, RNA. 14: 2074-2085.
Vizioli MG. et al., 2010, Oncogene. 29 (26): 3835-44.

包装：20ug

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