重组人 IGF1 / IGF-I 蛋白|Insulin-like growth factor 1 (somatomedin C) Protein|技术资料|价

IGF1 / IGF-I蛋白产品信息
产品名称：重组人 IGF1 / IGF-I 蛋白|Insulin-like growth factor 1 (somatomedin C) Protein|技术资料|价格
别名: IGF-I, IGF1A, IGFI
表达方式: A DNA sequence encoding the mature form of human IGF1 isoform 1 (P05019-1) (Gly 49-Ala 118) was expressed and purified.
种属: Human
表达宿主: E.coli

IGF1 / IGF-I蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant mature form of human IGF1 consisting of 71 amino acids and has a calculated molecular mass of 7.8KDa.
缓冲液: Lyophilized from sterile 30%Acetonitrile，0.1%TFA.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
IGF1 / IGF-I蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

IGF1 / IGF-I蛋白背景综述
Insulin-like growth factor I, also known as mechano growth factor, somatomedin-C, IGF-I and IGF1, is a secreted protein which belongs to the?insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ) and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by growth hormone and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation.
参考文献
Dull TJ. et al., 1984, Nature. 310: 777-81.
Bell GI. et al., 1984, Nature. 310: 775-7.
Cooke RM. et al., 1991, Biochemistry. 30: 5484-91.
Sandberg-Nordqvist A-C. et al., 1992, Brain Res Mol Brain Res. 12: 275-7.

包装：5ug  100ug

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