重组小鼠 FGF18 / FGF-18 蛋白|FGF18 / FGF-18 Protein|产品详情|现货

FGF18 / FGF-18蛋白产品信息
产品名称：重组小鼠 FGF18 / FGF-18 蛋白|FGF18 / FGF-18 Protein|产品详情|现货
别名: Fgf18,  RP23-413O19.3,   D130055P09Rik,   FGF-18
表达方式: A DNA sequence encoding the mouse FGF18 (NP_032031.1) ( Met 1-Gly 207 ) was fused with a polyhistidine tag at the C-terminus
种属: Mouse
表达宿主: Human Cells

FGF18 / FGF-18蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 28
分子量: The secreted recombinant mouse FGF18 comprises 191 amino acids and has a predicted molecular mass of 22.5 kDa. As a result of glycosylation, it migrates as an approximately 30-35 kDa band in SDS-PAGE under reducing conditions
缓冲液: 
Lyophilized from sterile PBS , pH 7.4

FGF18 / FGF-18蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

FGF18 / FGF-18蛋白背景综述
Mouse Fibroblast growth factor 18, also known as FGF-18, and FGF18, is a secreted protein which belongs to the fibroblast growth factors (FGFs) family. FGFs and their high-affinity receptors contribute to the autocrine growth stimulation in several malignancies. FGF18 is abundantly expressed in mouse embryonic lungs. It plays roles in lung alveolar development during late embryonic lung development stages. The cell proliferation during the terminal saccular stage stimulated by FGF18 might play roles in the remodeling of the distal lung. FGF18 expression is up-regulated in colorectal tumours and is progressively enhanced during colon carcinogenesis reaching very high levels in carcinoma. FGF18 affects both tumour cells and tumour microenvironment in a pro-tumorigenic and pro-metastatic way. FGF18 is almost generally over-expressed in colon cancer and exerts pro-tumorigenic effects both in the epithelial and the stromal compartments by stimulating growth and survival of tumour cells, migration of fibroblasts and neovascularization. FGF18 has been shown to regulate chondrocyte proliferation and differentiation by signaling through FGF receptor 3 (FGFR3) and to regulate osteogenesis by signaling through other FGFRs. FGF18 regulates skeletal vascularization and subsequent recruitment of osteoblasts / osteoclasts through regulation of early stages of chondrogenesis and VEGF expression. FGF18 coordinates neovascularization of the growth plate with chondrocyte and osteoblast growth and differentiation.
参考文献
Ohbayashi, N. et al., 2002, Genes Dev. 16 (7): 870-9.
Usui, H. et al., 2004, Biochem Biophys Res Commun. 322 (3): 887-92.
Liu, Z. et al., 2007, Dev Biol. 302 (1): 80-91.
Reinhold, MI. et al., 2007, J Biol Chem. 282 (6): 3653-63.
Sonvilla, G. et al., 2008, Carcinogenesis. 29 (1):15-24.

包装：20ug

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