重组食蟹猴 aFGF / FGF1 蛋白|Fibroblast growth factor 1 (acidic) Protein|厂家价格|现货

aFGF / FGF1蛋白产品信息
产品名称：重组食蟹猴 aFGF / FGF1 蛋白|Fibroblast growth factor 1 (acidic) Protein|厂家价格|现货
别名: FGF1
表达方式: A DNA sequence encoding the cyno FGF1 (Phe16-Asp155) was expressed and purified  with an initial Met.
种属: Cynomolgus
表达宿主: E.coli

aFGF / FGF1 Protein QC Testing
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant cyno FGF1 consists of 141 amino acids and has a calculated molecular mass of 16 kDa. It migrates as an 16 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH 7.4, 20% glycerol.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

aFGF / FGF1 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

aFGF / FGF1蛋白背景综述
aFGF (Acidic fibroblast growth factor), also known as FGF1 (Fibroblast growth factor 1), FGF-acidic and HBGF-1 (Heparin-binding growth factor 1), is a member of the fibroblast growth factor (FGF) family. It is a powerful mitogen exhibiting strong action on numerous different cell types. FGF1 protein plays a role in various stages of development and morphogenesis, as well as in angiogenesis and wound healing processes. aFGF protein binds to cell surface receptors with high affinity with the prerequisite association of aFGF with heparan sulfate. The aFGF gene is a repressed target of p53. It inhibits both p53-dependent apoptosis and cell growth arrest via an intracrine pathway. Accordingly, aFGF and p53 pathways may interact in the cell to determine cell fate.
参考文献
Rothlein, R. et al.,1986, Journal of Immunology. 137 (4): 1270-4.
Yang, L. et al., 2005, Blood. 106 (2): 584-92.
Gorczynski, R.M., 2005, Curr Opin Invest Drugs. 6: 483-7.
Frijns, C.J. et al., 2002, Stroke. 33 (8): 2115-22.
Bella, J. et al., 1998, Proc Natl Acad Sci. 95 (8): 4140-5.

包装：50ug

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