重组人 FGFBP3 蛋白|FGFBP3 Protein|技术资料|产品详情

FGFBP3蛋白产品信息
产品名称：重组人 FGFBP3 蛋白|FGFBP3 Protein|技术资料|产品详情
别名: C10orf13, FGFBP3
表达方式: A DNA sequence encoding the human FGFBP3 ( Met 1- Gly 258) (Q8TAT2) was expressed, with a C-terminal polyhistidine tag.
种属: Human
表达宿主: Baculovirus-Insect cells

FGFBP3 Protein QC Testing
纯度: > 87 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Arg 27
分子量: The secreted recombinant human FGFBP3 consists of 243 amino acids and predicts a molecular mass of 26.4 KDa. The apparent molecular mass of the protein is approximately 33 Kda in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% gly, pH7.4.
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
FGFBP3 Protein Usage Guide
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
FGFBP3蛋白背景综述
FGFBP3 is a member of the fibroblast growth factor-binding protein family. Fibroblast growth factors (FGFs) play an important role in the regulation of cell migration, proliferation and differentiation. The fibroblast growth factor-binding protein (FGF-BP) binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. After injury to murine and human skin, the expression of FGF-BP is increased, especially in keratinocytes. It is generally thought that this upregulation is achieved by major keratinocyte mitogens present at the wound site. FGFBP3 is a protein that exhibits fibroblast growth factor binding (orthology) and heparin binding (orthology). It is found that FGFBP3 is a positive regulator of fibroblast growth factor receptor signaling pathway and vascular permeability. It interacts with 2,3,7,8-tetrachlorodibenzodioxine, benzopyrene and valproic acid.
参考文献
Abuharbeid S. et al., 2006, Int J Biochem Cell Biol. 38 (9): 1463-8.
Lange LG. et al., 1976, Biochemistry. 15 (21): 4687-93.
Czubayko F. et al., 1997, Nat Med. 3 (10): 1137-40.

包装：20ug

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