Mouse Betacellulin / BTC Protein\重组小鼠 BTC / Betacellulin 蛋白|厂家现货|价格

Mouse Betacellulin / BTC蛋白产品信息
产品名称：Mouse Betacellulin / BTC Protein\重组小鼠 BTC / Betacellulin 蛋白|厂家现货|价格
Synonym: Btc  ,  Bcn
表达方式: A DNA sequence encoding the mouse BTC (NP_031594.1) extracellular domain (Met 1-Gln 118) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus
种属: Mouse 
表达宿主: Human Cells

Mouse Betacellulin / BTC蛋白质控指标
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE:
内**: < 1.0 EU per μg of the protein as determined by the LAL method.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 32
分子量: The recombinant mouse BTC/Fc is a disulfide-linked homodimer. The reduced monomer consists of 335 amino acids and has a predicted molecular mass of 38 kDa. As a result of glycosylation, the apparent molecular mass of rm BTC /Fc monomer migrates with an apparent molecular mass of 50-55 kDa in SDS-PAGE under reducing conditions
缓冲液: 
Lyophilized from sterile PBS , pH 7.4

Mouse Betacellulin / BTC蛋白背景综述
Betacellulin, also known as BTC is a single-pass type I membrane protein. Betacellulin is synthesized in several tissues and tumor cells. It is predominantly expressed in pancreas and small intestine. The expression of Betacellulin is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. Betacellulin belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin was initially described, purified and cloned from a mouse insulinoma cell line. It is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. Betacellulin binds and activates ErbB-1 and ErbB-4 homodimers. Betacellulin stimulated gastrointestinal growth, the increased responsiveness of the terminal ileum and colon suggesting therapeutic potential in disease conditions in which ileal or colonic re-growth is desirable. Betacellulin further stimulated a diuresis suggesting an additional role in fluid homeostasis.
参考文献
Dunbar, AJ. et al., 2000, Int J Biochem Cell Biol. 32 (8): 805-15.
Howarth, GS. et al., 2003, Growth Factors. 21 (2): 79-86.
Moon,WS. et al., 2006, Hum Pathol. 37 (10): 1324-32.
Mummery, RS. et al., 2007, Glycobiology. 17 (10): 1094-103.
Dunbar, AJ. et al., 2001, J Mol Endocrinol. 27 (2): 239-47.

包装：5ug  20ug

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