重组小鼠 EREG / epiregulin 蛋白|Mouse Epiregulin / EREG Protein|技术资料|价格

Epiregulin / EREG蛋白产品信息
产品名称：重组小鼠 EREG / epiregulin 蛋白|Mouse Epiregulin / EREG Protein|技术资料|价格
别名: EPR,    MGC36144
表达方式: A DNA sequence encoding the mature form of mouse EREG ( Q61521 )  ( Val 56 - Leu 101 ) was fused with the Fc region of human IgG1 at the N-terminus
种属: Mouse
表达宿主: Human Cells

Epiregulin / EREG蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu
分子量: The recombinant mouse EREG / Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 306 amino acids and has a predicted molecular mass of 33.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rmEREG / Fc monomer is approximately 37 kDa
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

Epiregulin / EREG蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Epiregulin / EREG蛋白背景综述
Mouse epiregulin, also known as EREG, is a secreted and a single-pass type I membrane protein which belongs to the epidermal growth factor family. Epiregulin / EREG contains one EGF-like domain. Epiregulin / EREG is expressed predominantly in the placenta and peripheral blood leukocytes. High levels of Epiregulin / EREG were detected in carcinomas of the bladder, lung, kidney and colon. Epiregulin / EREG may be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and / or angiogenesis. Epiregulin / EREG can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. The secondary structure at the C-terminus Epiregulin / EREG is different from other epidermal growth factor family ligands because of the lack of hydrogen bonds. The structural difference at the C-terminus may provide an explanation for the reduced binding affinity of epiregulin to the ERBB receptors.
参考文献
Toyoda H., et al., 1997, Biochem. J. 326:69-75.
Sato K., et al., 2003, FEBS Lett. 553:232-8.
Zhuang, S. et al., 2007, Am J Physiol Renal Physiol  293 (1):F219-26.

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