重组小鼠 EGFL7 / MEGF7 蛋白|Mouse Epidermal Growth Factor-like Protein 7|厂家现货|价格

Mouse EGFL7 / MEGF7蛋白产品信息
产品名称：重组小鼠 EGFL7 / MEGF7 蛋白|Mouse Epidermal Growth Factor-like Protein 7|厂家现货|价格
别名: Eif2c2, Ago2, ENSMUSG00000072493, Gerp95, Gm10365, KIAA4215, mKIAA4215
表达方式: A DNA sequence encoding the mouse EGFL7 isoform 1 ( Q9QXT5-1 ) ( Glu 22 - Leu 275 ) was fused with a polyhistidine tag at the N-terminus
种属: Mouse
表达宿主: Baculovirus

Mouse EGFL7 / MEGF7蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant mouse EGFL7 consists of 273 amino acids and has a calculated molecular mass of 29.8 kDa. It migrates as an approximately 34 kDa band in SDS-PAGE under reducing conditions
缓冲液: Lyophilized from sterile 100 mM Glycine, 10 mM NaCl, 10% gly, pH 7.0
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
Mouse EGFL7 / MEGF7蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Mouse EGFL7 / MEGF7蛋白背景综述
Mouse Epidermal growth factor-like protein 7, also known as EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7, Vascular endothelial statin, NOTCH4-like protein and EGFL7, is a secreted protein which contains two EGF-like domains and one EMI domain. EGFL7 was identified by a number of groups as a putative secreted factor produced by the vascular endothelial cells ( ECs ). EGFL7 is described as a novel endothelial cell-derived factor involved in the regulation of the spatial arrangement of cells during vascular tube assembly. With its impact on tubulogenesis and vessel shape EGFL7 joined the large family of molecules governing blood vessel formation. EGFL7 regulates midline angioblast migration in zebrafish embryos-a key step in vascular tubulogenesis. EGFL7 is tightly associated with the extracellular matrix ( ECM ), and it supports EC migration either as a single factor or in combination with other ECM molecules. EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning. Our study indicates that the molecular composition of the ECM influences vascular morphogenesis. EGFL7 also regulates vascular tubulogenesis. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate.
参考文献
Fitch,M.J. et al., 2004, Dev Dyn. 230 (2):316-24.
Schmidt,M. et al., 2007, Novartis Found Symp. 283 :18-28.
Campagnolo,L.et al., 2008, Gene Expr Patterns  8 (6):389-96.
Picuric,S. et al., 2009, Protein Expr Purif. 68 (1):1-6.
Nikolic,I. et al., 2010, J Angiogenes Res. 2 (1): 9.

包装：5ug  20ug

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