重组人 HBEGF / DTR 蛋白|HBEGF / DTR Protein|厂家现货|参数

HBEGF / DTR蛋白产品信息
产品名称：重组人 HBEGF / DTR 蛋白|HBEGF / DTR Protein|厂家现货|参数
别名: HBEGF , DTR, DTS, DTSF, HEGFL
表达方式: A DNA sequence encoding the human HBEGF ( Q99075 ) ( Met 1 - Leu 148 ) without the C-terminal propeptide ( aa 149 - 208 ), was expressed and purified
种属: Human
表达宿主: Baculovirus

HBEGF / DTR蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Asp 63
分子量: The expressed pro form of human HBEGF consists of 148 amino acids and predicts a molecular mass of 16.4 kDa. The processed soluble HBEGF is a 9.7 kDa protein comprising 86 amino acids generated by proteolytic processing
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
HBEGF / DTR蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
HBEGF / DTR蛋白背景综述
Heparin-binding EGF-like growth factor, also known as HBEGF, Diphtheria toxin receptor and DTR, is a secreted protein which is released into the extracellular space and probably binds to a receptor. Proheparin-binding EGF-like growth factor is a single-pass type I membrane protein. HBEGF contains one EGF-like domain. HBEGF may be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. HBEGF is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. HBEGF also acts as a diphtheria toxin receptor. HBEGF induces trophoblast extravillous differentiation and prevents apoptosis. These functions are compromised in preeclampsia. HBEGF-mediated signaling significantly reduces trophoblast cell death at term and its deficiency in preeclampsia could negatively impact trophoblast survival.
参考文献
Higashiyama S., et al., 1991, Science 251:936-939.
Mitamura T., et al., 1995, J. Biol. Chem. 270:1015-1019.
Louie G.V., et al., 1997,Mol. Cell 1:67-78.
Imudia,A.N. et al., 2008, Placenta 29 (9):784-9.
Jessmon,P.  et al., 2009, Mol Reprod Dev. 76 (12):1116-27.

包装：10ｕｇ　５０ｕｇ

1、产品质量问题，在产品售出7日内提出异议并且产品未有损坏，试剂类产品，需要提供详细的检测数据，创赛负责免费退换货服务；
2、本产品属于消耗品，不提供质保服务；
3、所有产品售后问题，请直接联系我司，我们将会尽快为您响应处理
查询关键词：重组人 HBEGF / DTR 蛋白，HBEGF / DTR Protein，厂家现货，参数，原料药，大包装定制，现货促销，医药中间体，科学仪器，实验室耗材，生化试剂，创赛中国,细胞因子
CANSPEC品质提供的重组人 HBEGF / DTR 蛋白|HBEGF / DTR Protein|厂家现货|参数性能**，其优良的品质满足您不同实验的多种需求。
本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com或www.4006087598.com