重组小鼠 LRIG1 / LIG-1 蛋白|Mouse LRIG1 / LIG-1 Protein|技术资料|产品详情

LRIG1 / LIG-1蛋白产品信息
产品名称：重组小鼠 LRIG1 / LIG-1 蛋白|Mouse LRIG1 / LIG-1 Protein|技术资料|产品详情
别名: D6Bwg0781e, Img, LIG-1
表达方式: A DNA sequence encoding the extracellular domain of mouse LRIG1 ( NP_032403.2 ) ( Met 1 - Thr 794 ) was expressed, with a polyhistidine tag at the C-terminus
种属: Mouse
表达宿主: Human Cells

LRIG1 / LIG-1蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE:
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 35
分子量: The recombinant mouse LRIG1 consists of 771 amino acids and has a predicted molecular mass of 85 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm LRIG1 is approximately 90-100 kDa due to glycosylation
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
LRIG1 / LIG-1蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
LRIG1 / LIG-1蛋白背景综述
Mouse Leucine-rich repeats and immunoglobulin-like domains protein 1, also known as LIG-1 and LRIG1, is a single-pass type I membrane protein which is widely expressed. LRIG1 / LIG-1 contains 3 Ig-like C2-type (immunoglobulin-like) domains, 15 LRR (leucine-rich) repeats, 1 LRRCT domain and 1 LRRNT domain. LRIG1 / LIG-1 act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. LRIG1 / LIG-1 is an endogenous inhibitor of growth factor signaling and a proposed tumor suppressor. LRIG1 / LIG-1 may be overexpressed in prostate cancer. LRIG1 / LIG-1 is an important determinant of prostate cancer growth, and the implications of its expression on patient outcome depend on the clinical and biological circumstances. LRIG1 / LIG-1 evolved in gliomas as a rare feedback negative attenuator of EGFR and could offer a novel therapeutic target to treat patients with malignant gliomas.
参考文献
Hedman,H. et al., 2002, Acta Oncol. 41 (4):352-4.
Nilsson,J. et al., 2003, Cell Tissue Res. 312 (1):65-71.
Ye,F. et al., 2009, J Neurooncol. 94 (2):183-94.
Thomasson,M. et al., 2011, Int J Cancer. 128 (12):2843-52.

包装：20ug

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