重组狗 EGF / Epidermal Growth Facto 蛋白|Epidermal growth factor Protein |参数|现货

EGF / Epidermal Growth Facto蛋白产品信息
产品名称：重组狗 EGF / Epidermal Growth Facto 蛋白|Epidermal growth factor Protein |参数|现货
别名: CEGF
表达方式: A DNA sequence encoding the mature form of canine EGF (Q9BEA0) (Asn 973-Arg 1024) was fused with a polyhistidine tag at the N-terminus.
种属: Canine
表达宿主: E.coli
EGF / Epidermal Growth Facto蛋白质控指标

纯度: > 98 % as determined by SDS-PAGE.  SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant canine EGF consists of 68 amino acids and has a calculated molecular mass of 8.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of canine EGF is approximately 12 kDa.
缓冲液: Lyophilized from sterile PBS, pH7.5
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

EGF / Epidermal Growth Facto蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

EGF / Epidermal Growth Facto蛋白背景综述
Canine epidermal growth factor (EGF), also known as urogastrone (URG) since it was isolated from urine based on its inhibitory effect on gastric secretion, is the founding member of the EGF-family of growth factors. All the members of this protein family have highly similar structural and functional characteristics. EGF is initially synthesized as a 130 kDa single-pass transmembrane protein containing 9 EGF-like units and 9 LDL-receptor class B repeats. The mature soluble EGF is a 6 kDa peptide corresponding to the EGF unit located proximal to the transmembrane domain. EGF is expressed in kidney, salivary gland, cerebrum and prostate, and plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR. As a potent mitogen, EGF stimulates the growth of various epidermal and epithelial tissues both in vivo and in vitro. Furthermore, EGF is also identified as a magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4), a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion.
参考文献
Ciardiello F. et al., 1991, Proc Natl Acad Sci. 88: 7792-7796.
Gout I. et al., 1992, Biochem J. 288: 395-405.
Harris RC. et al., 2003, Exp Cell Res. 284: 2-13.
Dreux AC. et al., 2006, Atherosclerosis. 186: 38-53.
Groenestege WMT. et al., 2007, J Clin Invest. 117: 2260-2267.

包装：100ug  200ug

1、产品质量问题，在产品售出7日内提出异议并且产品未有损坏，试剂类产品，需要提供详细的检测数据，创赛负责免费退换货服务；
2、本产品属于消耗品，不提供质保服务；
3、所有产品售后问题，请直接联系我司，我们将会尽快为您响应处理
查询关键词：重组狗 EGF / Epidermal Growth Facto 蛋白，Epidermal growth factor Protein ，参数，现货，原料药，大包装定制，现货促销，医药中间体，科学仪器，实验室耗材，生化试剂，创赛中国,细胞因子
CANSPEC品质提供的重组狗 EGF / Epidermal Growth Facto 蛋白|Epidermal growth factor Protein |参数|现货性能**，其优良的品质满足您不同实验的多种需求。
本产品由上海创赛品质提供，欢迎咨询国内免费服务专线：400-608-7598，更多产品信息请登录www.canspecsci.com或www.4006087598.com