重组人 NRG4 蛋白|Neuregulin 4 Protein|产品详情|厂家

NRG4蛋白产品信息
产品名称：重组人 NRG4 蛋白|Neuregulin 4 Protein|产品详情|厂家
别名: HRG4
表达方式: A DNA sequence encoding the human NRG4 (Q8WWG1) extracellular domain (Pro 2-Phe 62) was expressed and purified, with additional two amino acids (Gly & Pro) at the N-terminus.
种属: Human
表达宿主: E.coli

NRG4蛋白质控指标
纯度: > 92 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gly
分子量: The recombinant human NRG4 consists of 63 amino acids and has a calculated molecular mass of 6.7 KDa as estimated in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile 50mM Tris, 50mM NaCl; pH 7.2
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
NRG4蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NRG4蛋白背景综述
NRG4(neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including: cardiac development, Schwann cell and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses. NRG4 contains 1 EGF-like domain. It activates type-1 growth factor receptors to initiating cell-to-cell signaling through tyrosine phosphorylation. NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. However, it does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
参考文献
Strausberg RL. et al., 2002, Proc Nat Acad Sci. 99 (26): 16899-903.
Harari D. et al., 1999, Oncogene. 18 (17): 2681-9.
Memon AA. et al., 2004, Br J Cancer. 91 (12): 2034-41.

包装：20ug

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