重组人 NRG1-alpha (ECD) 蛋白|Neuregulin 1 Protein|产品详情|参数

NRG1蛋白产品信息
产品名称：重组人 NRG1-alpha (ECD) 蛋白|Neuregulin 1 Protein|产品详情|参数
别名: ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, NDF, SMDF
表达方式: A DNA sequence encoding the human NRG1 isoform alpha (Q02297-1) extracellular domain (Ser 20-Lys 241)was fused with the Fc region of human IgG1 at the C-terminus.
种属: Human
表达宿主: Human Cells
NRG1蛋白质控指标

纯度: > 87 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 20
分子量: The recombinant human NRG1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 463 amino acids and has a calculated molecular mass of 51 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh NRG1/Fc monomer is approximately 60 kDa.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

NRG1蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

NRG1蛋白背景综述
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
参考文献
Nicodemus KK. et al., 2010, Arch Gen Psychiatry. 67 (10): 991-1001.
Tan W. et al., 2007, J Biol Chem. 282 (33): 24343-51.
Holmes WE. et al., 1992, Science. 256 (5060): 1205-10.

包装：50ug

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