重组人 EphrinB1 / EFNB1 蛋白|Ephrin-B1 / EFNB1 / ELK-L Protein|技术资料|现货

Ephrin-B1 / EFNB1 / ELK-L蛋白产品信息
产品名称：重组人 EphrinB1 / EFNB1 蛋白|Ephrin-B1 / EFNB1 / ELK-L Protein|技术资料|现货
别名: EFNB1  ,  RP3-496G1.1  ,   CFND  ,  CFNS,   EFL3 ,   EPLG2 ,   Elk-L, LERK2,   MGC8782
表达方式: A DNA sequence encoding the human EFNB1 ( NP_004420.1 ) extracellular domain ( Met 1 - Gly 232 ) was was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus
种属: Human
表达宿主: Human Cells

Ephrin-B1 / EFNB1 / ELK-L蛋白质控指标
纯度: (79.7+18.0) % as determined by SDS-PAGE SDS-PAGE
生物活性:Measured by its binding ability in a functional ELISA
Immobilized mouse EphB3 at 2 μg/ml ( 100 μl/well ) can bind human EFNB1 Fc chimera with a linear ranger of 1.56 - 25 ng/ml
内**: < 1.0 EU per μg of the protein as determined by the LAL method.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Leu 28
分子量: The recombinant human EFNB1/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 458 amino acids and predicts a molecular mass of 51.2 KDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 64 and 36 KDa due to glycosylation.
缓冲液: Lyophilized from sterile PBS, pH7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
Ephrin-B1 / EFNB1 / ELK-L蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage.  Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Ephrin-B1 / EFNB1 / ELK-L蛋白背景综述
The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. In molecular biology, ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers.  Ephrin-B1, also known as LERK-2, ELK-L, EFL-3, Cek5-L, and STRA-1, is a member of the ephrin ligand family which binds members of the Eph receptor family. Ephrin-B1 has been shown to bind EphA3, EphB1, EphB2, EphB3, and EphB4. The extracellular domains of human and mouse ephrin-B1 share 94% amino acid identity.
参考文献
Cerretti, DP. et al., 1995, Mol. Immunol. 32 (16): 1197-205.
Gale, NW. et al.,1996, Neuron.17 (1): 9-19.
Flanagan, J. et al., 1998, Annual Review of Neuroscience. 21: 309-45.
Holder, N. et al., 1999,  Development. 126 (10): 2033-44.
Wilkinson, DG. et al., 2001, Nat. Rev. Neurosci. 2 (3): 155-64.
Murai, KK. et al., 2003, Journal of Cell Science. 116 (Pt 14): 2823-32.

包装：50ug

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