EFNA5 / Ephrin-A5蛋白产品信息
产品名称：重组大鼠 EFNA5 / Ephrin-A5 蛋白|Ephrin A5 Protein|技术资料|现货
别名: AL-1, AV158822, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS
表达方式: A DNA sequence encoding the mature form of rat EFNA5 (P97605) (Met 1-Glu 202) was fused with the Fc region of human IgG1 at the C-terminus.
种属: Rat
表达宿主: Human Cells
EFNA5 / Ephrin-A5蛋白质控指标
纯度: >90 % as determined by SDS-PAGE. SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Phe 17
分子量: The recombinant rat EFNA5/Fc is a disulfide-linked homodimer. The reduced monomer comprises 423 amino acids and predicts a molecular mass of 48 kDa. The apparent molecular mass of the rat EFNA5/Fc monomer is approximately 55 kDa in SDS-PAGE under reducing conditions due to glycosylation.
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
EFNA5 / Ephrin-A5蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
EFNA5 / Ephrin-A5蛋白背景综述
Ephrin-A5, also known as AL-1, RAGS, or LERK-7 ( ligand for eph-related kinases, 7 ), is a member of the ephrin ligand family which binds the members of Eph receptor subfamily of tyrosine kinases. Based on their structure and sequence relationships, ephrins are divided into ephrin-A and ephrin-B class, and ephrin-A members are anchored to the membrane by GPI linkage. Ephrin-A5 is expressed with the highest levels in human ***** brain, heart, spleen, and ovary and human fetal brain, lung, and kidney. This ligand has been reported to bind Eph A2, Eph A3, Eph A4, Eph A5, Eph A6, Eph A7, Eph A8, and Eph B2 receptors. The interactions between Eph receptors and their ephrin ligands have been implicated in mediating developmental events, particularly in the nervous system through regulating cell migration and axon pathfinding. It has been reported that Ephrin-A5 prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The ephrins (EPH) and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases (RTKs), and have been involved in a variety of biological processes, especially in the nervous system and in erythropoiesis, such as axon guidance and topographic map formation, synaptic plasticity, angiogenesis, and meanwhile have possible contributions to tumor growth and metastasis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class which are anchored to the membrane by a GPI linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. 14 receptors and 8 ligands have been reported in mammals.
参考文献
Stein E. et al., 1999, J Neurosci. 19: 8885-93.
Wilkinson DG. 2001, Nat Rev Neurosci. 2: 155-164.
Cheng N. et al., 2002, Cytokine Growth Factor Rev. 13: 75-85.
Himanen JP. et al., 2004, Nat Neurosci. 7: 501-9.
Eberhart J. et al., 2004, J Neurosci. 24: 1070-8.
Irie F. et al., 2008, Proc Nat Acad Sci. 105: 12307-12.
包装：50ug
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