重组人 GM-CSF / CSF2 蛋白|GM-CSF Protein|产品详情|现货

GM-CSF蛋白产品信息
产品名称：重组人 GM-CSF / CSF2 蛋白|GM-CSF Protein|产品详情|现货
GM-CSF 别名: CSF2, GMCSF, MGC131935, MGC138897
表达方式: A DNA sequence encoding the mature form of human GM-CSF ( NP_000749.2 ) ( Ala 18 - Glu 144 ) was fused with the Fc region of human IgG1 at the N-terminus.
种属: Human
表达宿主: Human Cells

GM-CSF蛋白质控指标
纯度: > 97% as determined by SDS-PAGE SDS-PAGE
生物活性:Measured by its binding ability in a functional ELISA
Immobilized CD131 at 10 μg/mL ( 100 μl/well ) can bind recombinant human GM-CSF / Fc with a linear range of 0.032 - 4 μg/ml
内**: < 1.0 EU per μg of the protein as determined by the LAL method.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 20
分子量: The recombinant human GM-CSF/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 364 amino acids and has a predicted molecular mass of 41 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh GM-CSF/Fc monomer is approximately 48-55 kDa due to glycosylation.
缓冲液: Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50 mM Tris, pH 7.5
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GM-CSF 蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GM-CSF 蛋白背景综述
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells. GM-CSF is secreted by a variety of cell types including macrophages, T cells, mast cells, endothelial cells and fibroblasts. This cytokine has a central role in governing the proliferation, maturation, differentiation and function of granulocyte and macrophage lineage populations, as well as the migration of endothelial cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target.
参考文献
Frolova, E.I. et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88: 4821-4824
Hamilton J.A. et al., 2002, Trends Immunol. 23: 403-408.
Ebner, K. et al., 2003, Blood, 102: 192-199.
Kato,T. et al., 2008, J. Interferon Cytokine Res. 28: 235-243.
Volmar, C.H. et al., 2008, Cytokine. 42: 336-344.

包装：20ug

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