重组人 / 食蟹猴 M-CSF / CSF-1 蛋白|Macrophage Colony-Stimulating Factor 1 Protein|厂家|价格

M-CSF / CSF-1蛋白产品信息
产品名称：重组人 / 食蟹猴 M-CSF / CSF-1 蛋白|Macrophage Colony-Stimulating Factor 1 Protein|厂家|价格
别名: RP11-195M16.2,  MCSF,  MGC31930
表达方式: A DNA sequence encoding the N-terminal fragment ( Met 1 - Asn 190 ) of human CSF1 ( P09603-1 ) was fused with a polyhistidine tag at the C-terminus. Human and Cynomolgus CSF1 sequences are identical.
种属: Human
表达宿主: Human Cells

M-CSF / CSF-1蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Glu 22
分子量: The recombinant human CSF1 consists of 169 amino acids and predictes a molecular mass of 19.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhCSF1 is approximately 27-32 kDa band due to glycosylation
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

M-CSF / CSF-1蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

M-CSF / CSF-1蛋白背景综述
Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Macrophage colony-stimulating factor (MCSF) is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF / CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF / CSF-1 may also be involved in development of the placenta. The active form of M-CSF / CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF / CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF / CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
参考文献
Pandit J. et al., 1992, Science 258:1358-1362.
Tokai,M. et al., 2000, J Bacteriol. 182 (10):2865-8.
Fan,X. et al., 2001, Am J Physiol Endocrinol Metab. 280 (1):E103-11
Frangogiannis,N.G. et al., 2003, Am J Physiol Heart Circ Physiol. 285 (2): H483-92.
Cupp,J.S. et al., 2007, Am J Surg Pathol. 31 (6):970-6.

包装：5ug  20ug 

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