重组人 GM-CSF / CSF2 蛋白|GM-CSF / CSF2 Protein|参数|现货

GM-CSF / CSF2蛋白产品信息
产品名称：重组人 GM-CSF / CSF2 蛋白|GM-CSF / CSF2 Protein|参数|现货
别名: CSF2, GMCSF, MGC131935, MGC138897
表达方式: A DNA sequence encoding the mature form of human GM-CSF (NP_000749.2) (Ala 18-Glu 144) was expressed, with a polyhistidine tag at the N-terminus.
种属: Human
表达宿主: Human Cells

GM-CSF / CSF2蛋白质控指标
纯度: > 92 % as determined by SDS-PAGE.  SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: His
分子量: The recombinant human GM-CSF consists of 147 amino acids and has a predicted molecular mass of 16.9 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh GM-CSF is approximately 24-27 kDa due to glycosylation.
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

GM-CSF / CSF2蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

GM-CSF / CSF2蛋白背景综述
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells. GM-CSF is secreted by a variety of cell types including macrophages, T cells, mast cells, endothelial cells and fibroblasts. This cytokine has a central role in governing the proliferation, maturation, differentiation and function of granulocyte and macrophage lineage populations, as well as the migration of endothelial cells. The active form of the protein is found extracellularly as a homodimer, and the encoding gene is localized to a related gene cluster at chromosome region 5q31 which is known to be associated with 5q-syndrome and acute myelogenous leukemia. As a part of the immune/inflammatory cascade, GM-CSF promotes Th1 biased immune response, angiogenesis, allergic inflammation, and the development of autoimmunity, and thus worthy of consideration for therapeutic target.
参考文献
Frolova, E.I. et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88: 4821-4824
Hamilton J.A. et al., 2002, Trends Immunol. 23: 403-408.
Ebner, K. et al., 2003, Blood, 102: 192-199.
Kato,T. et al., 2008, J. Interferon Cytokine Res. 28: 235-243.
Volmar, C.H. et al., 2008, Cytokine. 42: 336-344.

包装：5ug

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