重组人 CCL5 蛋白|Chemokine (C-C motif) ligand 5, Protein|产品详情|参数

RANTES蛋白产品信息
产品名称：重组人 CCL5 蛋白|Chemokine (C-C motif) ligand 5, Protein|产品详情|参数
RANTES 别名: CCL5,D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228
表达方式: A DNA sequence encoding the human RANTES (NP_002976.2) (Met 1- Ser 91) was fused with the C-terminal polyhistidine-tagged human Fractalkine mucin-stalk (Phe 101- Gln 341) at the C-terminus.
种属: Human
表达宿主: Human Cells

RANTES蛋白质控指标
纯度: > 95%, as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per 1μg of the protein as determined by the LAL method.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ser 24
分子量: The recombinant human RANTES/Mucin stalk chimera consists of 318 amino acids and has a predicted molecular mass of 34 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh RANTES/Mucin stalk chimera is approximately 50-80 kDa due to glycosylation.
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

RANTES蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted and be used as soon as possible. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

RANTES蛋白背景综述
Chemokine (C-C motif) ligand 5, also known as CCL5 and RANTES (acronym for Regulated upon Activation, Normal T cell Expressed and presumably Secreted), is an 8 kDa protein classified as a member of the β (C-C) chemokine subfamily of proinflammatory cytokines. CCL5 is chemotactic for T cells,eosinophils, and basophils, and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines that are released by T cells, CCL5 induces the proliferation and activation of certain natural killer (NK) cells. It is also an HIV-suppressive factor released from CD8+ T cells and has been shown to interact with CCR3, CCR5, and CCR1. Fractalkine (also known as CX3CL1) is one of two known transmembrane chemokines, and contains a chemokine domain tethered on a long mucin-like stalk within the ECD. Fractalkine binds with high affinity to CX3CR1 and mediates the tight binding of leukocytes expressing CX3CR1 independently of G protein activation. The chemokine domain of human Fractalkine is replaced by human RANTES in the purified RANTES/mucin-like stalk chimera.
参考文献
Donlon, T.A. et al., 1990, Genomics. 6 (3): 548-553.
Maghazachi. et al., 1996, Eur J Immunol. 26: 315-319.
Daugherty, B. L. et al., 1996, J. Exp. Med.183 (5): 2349-2354.
Proudfoot, A.E. et al., 1996, J. Biol. Chem. 271: 2599-2603.
Elsner, J. et al., 1997, Eur. J. Immunol. 27:2892-2898.

包装：20ug

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