重组人 CX3CL1 / NTN 蛋白|Chemokine (C-X3-C Motif) Ligand 1 Protein|生产厂家|价格

CX3CL1 / NTN / Fractalkine蛋白产品信息
产品名称：重组人 CX3CL1 / NTN 蛋白|Chemokine (C-X3-C Motif) Ligand 1 Protein|生产厂家|价格
CX3CL1 别名: ABCD-3, C3Xkine, CXC3, CXC3C, NTN, NTT, SCYD1, fractalkine, neurotactin
表达方式: A DNA sequence encoding the human CX3CL1 (NP_002987.1) extracellular domain ( Met 1-Arg 339 ) with a C-terminal polyhistidine tag was expressed.
种属: Human
表达宿主: Human Cells

CX3CL1 / NTN / Fractalkine蛋白质控指标
纯度: > 95%, as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per 1μg of the protein as determined by the LAL method.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Gln 25
分子量: The secreted recombinant human CX3CL1 comprises 329 amino acids with a predicted molecular mass of 35 kDa. As a result of different glycosylation, rhCX3CL1 migrates between 50-70 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CX3CL1 / NTN / Fractalkine蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage and usage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CX3CL1 / NTN / Fractalkine Protein Related Products & Topics

CX3CL1 / NTN / Fractalkine蛋白背景综述
Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a large cytokine protein containing multiple domains and is the only known member of the CX3C chemokine family. It is also commonly known as fractalkine (in humans) and neurotactin (in mice). The polypeptide structure of CXC3L1 differs from the typical structure of other chemokines. Mature human CX3CL1 consists of a 76 aa residue chemokine domain, a 241 aa residue stalk region containing 17 degenerate mucin-like repeats, a 19 aa residue transmembrane segment and a 37 aa residue cytoplasmic domain. The extracellular domain of human CX3CL1 can be released, possibly by proteolysis at the dibasic cleavage site proximal to the membrane, to generate soluble CX3CL1. Soluble CX3CL1 potently chemoattracts T cells and monocytes, while the cell-bound CX3CL1 promotes strong adhesion of leukocytes to activated endothelial cells where it is primarily expressed. CX3CL1 elicits its adhesive and migratory functions by interacting with the chemokine receptor CX3CR1.

参考文献
Bazan, J. F.,et al.,1997, Nature. 385: 640-644.
Imai,T. et al., 1997, Cell. 91: 521-530.
Nomiyama, H. et al., 1998, Cytogenet. Cell Genet. 81: 10-11.
Papadopoulos, E. et al., 1999, Eur. J. Immunol. 29 (8): 2551-2559.
Umehara, H. et al., 2004, Arterioscler. Thromb. Vasc. Biol. 24 (1): 34-40.

包装：5ug  20ug 

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