重组人 CCL8 / MCP-2 蛋白|CCL8 / MCP-2 Protein|技术资料|参数

CCL8 / MCP-2蛋白产品信息
产品名称：重组人 CCL8 / MCP-2 蛋白|CCL8 / MCP-2 Protein|技术资料|参数
别名: MCP2, SCYA10, SCYA8
表达方式: A DNA sequence encoding the human CCL8 ( P80075-1 ) ( Gln 24 - Pro 99 ) was fused with the SUMO tag at the N-terminus .
种属: Human
表达宿主: E. coli

CCL8 / MCP-2蛋白质控指标
纯度: >  90% as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human CCL8 consisting of 187 amino acids and has a calculated molecular mass of 21.7 kDa. The apparent molecular mass of the protein is approximately 30 kDa in SDS-PAGE under reducing conditions
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CCL8 / MCP-2蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CCL8 / MCP-2蛋白背景综述
C-C motif chemokine 8, also known as Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, Small-inducible cytokine A8, CCL8 and MCP-2, is a secreted protein which belongs to the intercrine beta (chemokine CC) family. Highest expression of CCL8 / MCP-2 is found in the small intestine and peripheral blood cells. Intermediate levels of CCL8 / MCP-2 is seen in the heart, placenta, lung, skeletal muscle, thymus, colon, ovary, spinal cord and pancreas. Low levels of CCL8 / MCP-2 is seen in the brain, liver, spleen and prostate. CCL8 / MCP-2 is a chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils. It may play a role in neoplasia and inflammatory host responses. CCL8 / MCP-2 can bind heparin. CCL8 / MCP-2 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B and CCR5. CCL8 / MCP-2 is also a potent inhibitor of HIV-1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV-1. Graft-versus-host disease ( GVHD ) is a life-threatening complication of hematopoietic stem-cell transplantation (HSCT). CCL8 / MCP-2 is a promising specific serum marker for the early and accurate diagnosis of GVHD.
参考文献
van Damme J., et al., 1992, J. Exp. Med. 176:59-65.
Kim K.-S., et al., 1996, FEBS Lett. 395:277-82.
Proost P, et al., 1996, J. Leukoc. Biol. 59 (1): 67-74.
Proost P., et al., 1998, J. Immunol. 160:4034-41.
Blaszczyk J, et al., 2000, Biochemistry. 39 (46): 14075-81.
Struyf,S. et al., 2009, Eur J Immunol.39 (3):843-57.

包装：10ug

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