重组小鼠 CXCL2 / GRO2 / MIP-2 蛋白|Mouse CXCL2 / GRO2 Protein|生产厂家|现货

CXCL2 / GRO2蛋白产品信息

产品名称：重组小鼠 CXCL2 / GRO2 / MIP-2 蛋白|Mouse CXCL2 / GRO2 Protein|生产厂家|现货
别名: CINC-2a,  GROb,  Gro2,  MIP-2,  MIP-2a,  Mgsa-b,  Mip2,  Scyb,  Scyb2
表达方式: A DNA sequence encoding the mature form of mouse CXCL2 ( P10889-1 ) ( Ala 28 - Asn 100 ) was fused with a N-terminal polyhistide-tagged SUMO tag at the N-terminus
种属: Mouse
表达宿主: E. coli

CXCL2 / GRO2蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant mouse CXCL2 consisting of 189 amino acids and has a calculated molecular mass of 21.2 kDa. It migrates as a 30 kDa band in SDS-PAGE under reducing conditions
缓冲液: Lyophilized from sterile 0.1% TFA, pH 2.9
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL2 / GRO2蛋白使用指南

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CXCL2 / GRO2蛋白背景综述
Mouse C-X-C motif chemokine 2, also known as growth-regulated protein beta, macrophage inflammatory protein 2-alpha, MIP2-alpha, CXCL2 and GRO2, is a secreted protein which belongs to the intercrine alpha (chemokine CxC) family. CXCL2 / MIP2-alpha is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. CXCL2 / MIP2-alpha has been known to regulate immune functions mainly by chemo-attracting neutrophils. It is produced by activated monocytes and neutrophils and expressed at sites of inflammation. CXCL2 / MIP2-alpha is Hematoregulatory chemokine, which suppresses hematopoietic progenitor cell proliferation. CXCL2 / MIP2-alpha can be induced by receptor activator of NF-kappaB ligand, the osteoclast (OC) differentiation factor, through JNK and NF-kappaB signaling pathways in OC precursor cells. CXCL2 in turn enhanced the proliferation of OC precursor cells of bone marrow-derived macrophages (BMMs) through the activation of ERK. Knockdown of CXCL2 inhibited both the proliferation of and the ERK activation in BMMs. During osteoclastogenesis CXCL2 stimulated the adhesion and the migration of BMMs. CXCL2 is a novel therapeutic target for inflammatory bone destructive diseases.
参考文献
Pelus LM, et al., 2006, Exp Hematol. Aug;34(8):1010-20.
De Plaen,I.G. et al., 2006, Immunology. 118 (2):153-63.
Rubio,N. et al., 2006, Cell Immunol. 239 (1):31-40.
Hohl,T.M. et al., 2008,J Infect Dis. 198 (2):176-85.
Ha,J. et al., 2010, J Immunol. 184 (9):4717-24.

包装：20ug

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