重组人 CCL17 / TARC / SCYA17 蛋白|CCL17 / SCYA17 Protein|技术资料|生产厂家

CCL17 / SCYA17蛋白产品信息
产品名称：重组人 CCL17 / TARC / SCYA17 蛋白|CCL17 / SCYA17 Protein|技术资料|生产厂家
别名: A-152E5.3, ABCD-2, MGC138271, MGC138273, SCYA17,  TARC
表达方式: A DNA sequence encoding the human CCL17 ( Q92583-1 ) ( Met 1 - Ser 94 ) was expressed and purified
种属: Human
表达宿主: Baculovirus

CCL17 / SCYA17蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: < 1.0 EU per μg of the protein as determined by the LAL method
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Ala 24
分子量: The secreted recombinant human CCL17 consists of 71 amino acids and predicts a molecular mass of 8 kDa. It migrates as an approximately 10 kDa band in SDS-PAGE under reducing conditions
缓冲液: Lyophilized from sterile PBS , pH 7.5
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CCL17 / SCYA17蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CCL17 / SCYA17蛋白背景综述
C-C motif chemokine 17, also known as CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CCL17 and SCYA17, is a secreted protein which belongs to the intercrine beta (chemokine CC) family. Chemokines are known to regulate the steady-state and inflammatory migration of cutaneous dendritic cells (DCs). The beta-chemokine CCL17, a ligand of CCR4, is inducibly expressed in a subset of DCs and is strongly up-regulated in atopic diseases. CCL17 / SCYA17 is constitutively expressed in the thymus and is produced by dendritic cells (DC), endothelial cells, keratinocytes (KC) and fibroblasts. CCL17 / SCYA17 is expressed at high levels in thymus and at low levels in the lung, colon and small intestine. CCL17 / SCYA17 is a chemotactic factor for T-lymphocytes but not monocytes or granulocytes. It may play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. CCL17 / SCYA17 binds to CCR4.Chemokine receptor CCR4 and its ligands (CCL17 and CCL22) are important for the recruitment of memory T cells into the skin in various cutaneous immune diseases.
参考文献
Belperio,J.A. et al., 2004, J Immunol. 173 (7):4692-8.
Carpenter,K.J. et al., 2005, Infect Immun. 73 (11):7198-207.
Saeki,H. et al., 2006, J Dermatol Sci. 43 (2):75-84.
Niens,M. et al., 2008, Br J Haematol. 140 (5):527-36.
Stutte,S. et al., 2010, Proc Natl Acad Sci. USA 107 (19):8736-41.

包装：20ug

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