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Cynomolgus CXCL13 / BCA-1蛋白产品信息 产品名称:重组食蟹猴 CXCL13 / BCA-1 / BLC 蛋白|Cynomolgus CXCL13 / BCA-1 Protein|产品详情|价格 别名: cxcl13 表达方式: A DNA sequence encoding the mature form of Cynomolgus ( Macaca fascicularis ) CXCL13 ( Val 23 - Pro 109 ) was expressed, with an N-terminal polyhistidine tag 种属: Cynomolgus 表达宿主: E.coli Cynomolgus CXCL13 / BCA-1蛋白质控指标 纯度: > 90 % as determined by SDS-PAGE SDS-PAGE 内**: Please contact us for more information. 稳定性: Samples are stable for up to twelve months from date of receipt at -70℃ 预测N端: His 分子量: The recombinant cynomolgus CXCL13 consists of 103 amino acids and has a calculated molecular mass of 12.4 kDa. The apparent molecular mass of the recombinant protein is approximately 14 kDa in SDS-PAGE under reducing conditions due to glycosylation 缓冲液: Lyophilized from sterile 10 mM Tris, 250mM NaCl, pH 8.0 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. Cynomolgus CXCL13 / BCA-1蛋白使用指南 储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. Cynomolgus CXCL13 / BCA-1蛋白背景综述 Cynomolgus CXCL13, also known as BCA-1 ( B-cell-attracting chemokine-1 ) or BLC ( B-lymphocyte chemoattractant ), is a major regulator of B-cell trafficking. CXCL13 is a small cytokine belonging to the CXC chemokine family. CXCL13 and its receptor CXCR5 control the organization of B cells within follicles of lymphoid tissues. CXCL13 is known to dictate homing and motility of B cells in lymphoid tissue and has been implicated in the formation of ectopic lymphoid tissue in chronic inflammation. The increased level of CXCL13 is a feature of systemic lupus erythematosus (SLE) that correlates with disease activity. Furthermore, CXCL13 might be a readily available surrogate marker to monitor the extent of aberrant B-cell (dys-)function. The vascular endothelial BCA-1 expression may be consequent to transcytosis. In Primary central nervous system lymphoma (PCNSL), expression of BCA-1 by malignant lymphocytes and vascular endothelium may influence tumor development and localization to central nervous system (CNS). CXCL13 expression is a distinctive feature of angioimmunoblastic T-cell lymphoma, providing further support for the germinal center T-helper cell as the cell of origin for this neoplasm. Furthermore, CXCL13, a chemokine that may participate in tumor pathogenesis and is a potential target for novel therapies. 参考文献 Ansel KM. et al., 2000, Nature. 406 (6793): 309-14. Schiffer L. et al., 2009, Nephrol Dial Transplant. 24(12): 3708-12. Rupprecht TA. et al., 2009, J Neuroinflammation. 6: 42. Smith JR. et al., 2003, Blood. 101(3): 815-21. Grogg KL. et al., 2006, Mod Pathol. 19(8): 1101-7. Falkenhagen KM. et al., 2005, Am J Ophthalmol. 140(2): 335-7. 包装:20ug
1、产品质量问题,在产品售出7日内提出异议并且产品未有损坏,试剂类产品,需要提供详细的检测数据,创赛负责免费退换货服务; 2、本产品属于消耗品,不提供质保服务; 3、所有产品售后问题,请直接联系我司,我们将会尽快为您响应处理 查询关键词:重组食蟹猴 CXCL13 / BCA-1 / BLC 蛋白,Cynomolgus CXCL13 / BCA-1 Protein,产品详情,价格,原料药,大包装定制,现货促销,医药中间体,科学仪器,实验室耗材,生化试剂,创赛中国,细胞因子 CANSPEC品质提供的重组食蟹猴 CXCL13 / BCA-1 / BLC 蛋白|Cynomolgus CXCL13 / BCA-1 Protein|产品详情|价格性能**,其优良的品质满足您不同实验的多种需求。 本产品由上海创赛品质提供,欢迎咨询国内免费服务专线:400-608-7598,更多产品信息请登录www.canspecsci.com或www.4006087598.com
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