重组人 CXCL1 / MGSA / NAP-3 蛋白|C-X-C motif Ligand 1 / CXCL1 Protein|厂家现货|参数

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CXCL1蛋白产品信息
产品名称：重组人 CXCL1 / MGSA / NAP-3 蛋白|C-X-C motif Ligand 1 / CXCL1 Protein|厂家现货|参数
别名: 
FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
表达方式: 
A DNA sequence encoding the mature form of human CXCL1 ( P09341-1 ) ( Ala 35 - Asn 107 ) was fused with the polyhistidine-tagged NusA tag at the N-terminus
种属: Human
表达宿主: E. coli

CXCL1蛋白质控指标
纯度: > 95 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human CXCL1 consisting of 586 amino acids and migrates as an approximately 65 kDa band as predicted in SDS-PAGE under reducing conditions
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CXCL1蛋白使用指南
储存方法:  Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:  A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CXCL1蛋白背景综述
The Chemokine ( C-X-C motif ) Ligand 1, CXCL1, also known as melanoma growth-stimulatory activity/growth-regulated protein alpha ( MGSA-a ), a memer of CXC chemokine family, plays a major role in inflammation, angiogenesis, tumorigenesis, and wound healing. Recently, it have been extensively related to cellular transformation, tumor growth, homing, and metastasis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine CXCL1 elicits its effects by signaling through the chemokine receptor CXCR2. CXCL1 plays a critical nonredundant role in the development of experimental Lyme arthritis and carditis via CXCR2-mediated recruitment of neutrophils into the site of infection. CXCL1 might limit tumor growth by reinforcing senescence early in tumorigenesis, and it is a potent neutrophil chemoattractant with recognized roles in angiogenesis and inflammation. CXCL1 is a novel immediate PTH / PTHrP-responsive gene. CXCL1 may act as a chemoattractant for osteoclast precursors. CXCL1 may also have important pro-nociceptive effects via its direct actions on sensory neurons, and may induce long-term changes that involve protein synthesis.
参考文献
Dhawan P. et al., 2002, J Leukoc Biol. 72(1): 9-18.
Iida N. et al., 1990, Mol. Cell. Biol. 10 (10): 5596-9.
Becker S. et al., 1994, Am. J. Physiol. 266 (3 Pt 1): L278-86.
Moser B. et al., 1990, J. Exp. Med. 171 (5): 1797-802.
Ritzman AM. et al., 2010, Infect Immun. 78(11): 4593-600.
Acosta JC. et al., 2009, Cancer Res. 69(6): 2167-70.
Onan D. et al., 2009, Endocrinology. 150(5): 2244-53.
Wang JG. et al., 2008, Mol Pain. 4: 38.

包装：20ug

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