重组人 CXCL9 / C-X-C motif chemokine 9 蛋白|C-X-C motif chemokine 9 / CXCL9 Protein

CXCL9蛋白产品信息
产品名称：重组人 CXCL9 / C-X-C motif chemokine 9 蛋白|C-X-C motif chemokine 9 / CXCL9 Protein
别名: CMK, Humig, MIG, SCYB9, crg-10
表达方式: A DNA sequence encoding the human CXCL9 ( Q07325 ) ( Thr 23 - Thr 125 ) was expressed and purified
种属: Human
表达宿主: E.coli

CXCL9蛋白质控指标
纯度: > 90 % as determined by SDS-PAGE SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: 
The recombinant human CXCL9 comprises 104 amino acids and has a calculated molecular mass of 11.9 kDa. It migrates as an approximately 16 kDa band in SDS-PAGE under reducing conditions
缓冲液: Lyophilized from sterile PBS , pH 7.4
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CXCL9蛋白使用指南

储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CXCL9蛋白背景综述
C-X-C motif chemokine 9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, Small-inducible cytokine B9 and CXCL9, is a secreted protein which belongs to the intercrine alpha (chemokine CxC) family. CXC chemokines are particularly significant for leukocyte infiltration in inflammatory diseases. CXCL9 is a cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. CXCL9 binds to CXCR3. CXCR3 ligand CXCL9 is involved in regulation of the allergic response in the lung by regulation of lymphocyte activation and eosinophil recruitment. CXCL9 has immunomodulatory functions that are not mediated through a G-protein coupled receptor and may possess additional roles in host defenses against infection. Measurement of pretransplant serum CXCL9 levels might represent the tracking of a clinically useful parameter to identify subjects at high risk of acute rejection (AR) and graft failure. CXCL9 might be used for the individualization of immunosuppressive therapies.
参考文献
Thomas,M.S. et al., 2004, J Immunol. 173 (1):615-23.
Hasan,Z. et al., 2009, PLoS One. 4 (4):e5158.
Menke,J. et al., 2008, J Am Soc Nephrol. 19 (6):1177-89.
Rotondi,M. et al., 2010,Transpl Int. 23 (5):465-75.
Higurashi,M. et al., 2009, J Diabetes Complications. 23 (3):178-84.

包装：20ug

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