NCC2 / CCL14 ( aa 28-93 )蛋白产品信息
产品名称：重组人 NCC2 / CCL14 (aa 28-93) 蛋白|Chemokine (C-C motif) ligand 14 Protein|产品详情|价格
别名: CC-1, CC-3, CKB1, FLJ16015, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, MCIF, NCC-2, NCC2, SCYA14, SCYL2, SY14
表达方式: A DNA sequence encoding the amino acids (Gly 28-Asn 93) of human CCL14 (Q16627-1) was expressed, with a polyhistide tag at the N-terminus.
种属: Human
表达宿主: E. Coli
NCC2 / CCL14 ( aa 28-93 )蛋白质控指标
纯度: > 96 % as determined by SDS-PAGE. SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human CCL14 (aa 28-93) consisting of 77 amino acids and has a calculated molecular mass of 9.3 KDa. It migrates as an approximately 12 kDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, pH8.0
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
NCC2 / CCL14 ( aa 28-93 )蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
NCC2 / CCL14 ( aa 28-93 )蛋白背景综述
C-C motif chemokine 14, also known as Chemokine CC-1 / CC-3, HCC-1 / HCC-3, NCC-2, Small-inducible cytokine A14, CCL14 and NCC2, is a secreted protein which belongs to the?intercrine beta (chemokine CC) family. CCL14 / NCC2 is expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. CCL14 / NCC2 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. CCL14 / NCC2 induces intracellular Ca2+?changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. CCL14 / NCC2 enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1 (9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
参考文献
Schulz-Knappe P., et al., 1996, J. Exp. Med. 183:295-9.
Pardigol A., et al., 1998, Proc. Natl. Acad. Sci. USA. 95:6308-13.
Detheux M., et al., 2000, J. Exp. Med. 192:1501-8.
Richter R., et al., 2000, Biochemistry 39:10799-805.
包装：20ug
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