重组人 CCL7 / MCP3 蛋白|Chemokine (C-C motif) ligand 7 Protein|产品详情|参数

CCL7 / MCP3蛋白产品信息
产品名称：重组人 CCL7 / MCP3 蛋白|Chemokine (C-C motif) ligand 7 Protein|产品详情|参数
别名: FIC, MARC, MCP-3, MCP3, MGC138463, MGC138465, NC28, SCYA6, SCYA7
表达方式: A DNA sequence encoding the mature form of human CCL7 (NP_006264.2) (Gln 24-Leu 99) was expressed, with an initial Met at the N-terminus and a polyhistide tag at the C-terminus.
种属: Human
表达宿主: E. Coli

CCL7 / MCP3蛋白质控指标
纯度: > 92 % as determined by SDS-PAGE.  SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human CCL7 consisting of 87 amino acids and has a calculated molecular mass of 10.5 kDa. It migrates as an approximately 13 KDa band in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile 50mM Tris, 30%glycerol, pH7.5
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.
CCL7 / MCP3蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CCL7 / MCP3蛋白背景综述
C-C motif chemokine 7, also known as Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, MCP-3, Small-inducible cytokine A7, CCL7 and MCP3, is a secreted protein which belongs to the?intercrine beta (chemokine CC) family. Chemokines and chemokine receptors are pivotal regulators of cellular communication and trafficking. In addition to the approximately 20 chemokine receptors that have been cloned and described, various orphan receptors with a chemokine receptor-like structure are known. CCL7 / MCP3 is a chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. It augments monocyte anti-tumor activity. CCL7 / MCP3 also induces the release of gelatinase B. This protein can bind heparin. It also binds to CCR1, CCR2 and CCR3. Monocyte chemotactic protein 3 (MCP-3/CCL7), a CC chemokine able to attract and activate a large panel of leukocytes including natural killer cells and T lymphocytes, could be beneficial in antitumor therapy. CCL7 and CXCL10 play a critical role in mediating oxidative stress-induced neutrophilic airway inflammation.
参考文献
Michalec,L. et al., 2002, J Immunol. 168 (2):846-52.
Biber,K. et al., 2003, J Leukoc Biol. 74 (2):243-51.
Wetzel,K. et al., 2007, Int J Cancer. 120 (6):1364-71.
Hintzen,C. et al., 2008, J Immunol.181 (10):7341-9.

包装：20ug

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