重组人 CCL11 蛋白|Chemokine (C-C motif) ligand 11 Protein|产品详情|价格

CCL11蛋白产品信息
产品名称：重组人 CCL11 蛋白|Chemokine (C-C motif) ligand 11 Protein|产品详情|价格
别名: MGC22554, SCYA11
表达方式: A DNA sequence encoding the human CCL11 (P51671) (Gly 24-Pro 97) was expressed, with a polyhistide tag at the N-terminus.
种属: Human
表达宿主: E.coli

CCL11蛋白质控指标
纯度: > 97 % as determined by SDS-PAGE.  SDS-PAGE
内**: Please contact us for more information.
稳定性: Samples are stable for up to twelve months from date of receipt at -70℃
预测N端: Met
分子量: The recombinant human CCL11 consists of 93 amino acids and has a calculated molecular mass of 10.8 KDa. The apparent molecular mass of the protein is approximately 14 kDa in SDS-PAGE under reducing conditions.
缓冲液: Lyophilized from sterile PBS, 10%glycerol, pH7.5
Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
Please contact us for any concerns or special requirements.

CCL11蛋白使用指南
储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CCL11蛋白背景综述
Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: CC kemokines, C kemokines, CXC kemokines and CX3C kemokines. The CC kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called CC chemokine ligands (CCL)-1 to 28. CCL11 is a member of the CC chemokine ligands family. CCL11 is implicated in allergic responses through sel ectively recruiting eosinophils by inducing their chemotaxis. The effects of CCL11 are mediated by its binding to chemokine receptor. Increased CCL11 levels in blood plasma are associated with aging in mice.
参考文献
Laing KJ. et al., 2004, Developmental and comparative immunology. 28(5): 443-60.
Cocchi F. et al., 1995, Science. 270 (5243): 1811-5.
Villeda SA. et al., Nature. 477: 90-4.

包装：20ug

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