XCL1蛋白产品信息 产品名称:重组人 XCL1 蛋白|Chemokine (C motif) ligand 1 Protein|技术资料|现货 别名: ATAC, LPTN, LTN, SCM-1, SCM-1a, SCM1, SCM1A, SCYC1 表达方式: A DNA sequence encoding the human XCL1 (P47992) (Met 1- Gly 114) was expressed, fused with a polyhistidine tag at the C-terminus. 种属: Human 表达宿主: Baculovirus-Insect cells XCL1蛋白质控指标 纯度: > 85 % as determined by SDS-PAGE. SDS-PAGE 内**: < 1.0 EU per μg of the protein as determined by the LAL method 稳定性: Samples are stable for up to twelve months from date of receipt at -70℃ 预测N端: Val 22 分子量: The recombinant human XCL1 consists of 103 amino acids and predicts a molecular mass of 11.6 kDa. The apparent molecular mass of rhXCL1 is approximately 15-20 kDa in SDS-PAGE under reducing conditions. 缓冲液: Lyophilized from sterile 20mM, Tris 500mM Nacl , pH7.4 Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. XCL1蛋白使用指南 储存方法: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. XCL1蛋白背景综述 Chemokine (C motif) ligand (XCL1) is a member of the C-chemokine subfamily of XC chemokine family that is also known as lymphotactin. Chemokines are the largest family of cytokines, cause leukocyte mobilization through chemotaxis at sites of antigenic challenge or lesions. XCL1 is maily expressed in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and lower levels in lung, prostate gland and ovary. XCL1 differs from other chemokines in that it contains only a single disulfide bond and a mucin-like domain at its carboxy terminus that is glycosylated. Lymphotactin-XCL1 is a chemokine produced mainly by activated CD8+ T-cells and directs migration of CD4+ and CD8+ lymphocytes and natural killer (NK) cells. This chemokine attracts T cells. Experiments showed a reduction in XCL1 and XCR1 expression in allergic asthma regulatory T cell compared with healthy control and nonallergic asthmatic counterparts. This reduction in XCL1 expression was associated with the suboptimal regulatory function of regulatory T cell (Treg) in allergic asthma. Interestingly, incubation with recombinant human XCL1 significantly increased Treg-mediated suppression and cytotoxicity by up-regulating expression of XCL1 and chief effector molecules of Treg function. Altogether, these results suggest an association between dysregulated XCL1 expression and reduced Treg activities in AA, as well as a potential role of XCL1 in reversing defective Treg function in the disease. 参考文献 Nguyen KD. et al., 2008, J Immunol. 181 (8): 5386-95. Dong C. et al., 2005, J Immunol Methods. 302 (1-2): 136-44. Zavala-Flores LM. et al., 2009, Biotechnol Lett. 31 (2): 215-20. 包装:20ug
1、产品质量问题,在产品售出7日内提出异议并且产品未有损坏,试剂类产品,需要提供详细的检测数据,创赛负责免费退换货服务; 2、本产品属于消耗品,不提供质保服务; 3、所有产品售后问题,请直接联系我司,我们将会尽快为您响应处理 查询关键词:重组人 XCL1 蛋白,Chemokine (C motif) ligand 1 Protein,技术资料,现货,原料药,大包装定制,现货促销,医药中间体,科学仪器,实验室耗材,生化试剂,创赛中国,细胞因子 CANSPEC品质提供的重组人 XCL1 蛋白|Chemokine (C motif) ligand 1 Protein|技术资料|现货性能**,其优良的品质满足您不同实验的多种需求。 本产品由上海创赛品质提供,欢迎咨询国内免费服务专线:400-608-7598,更多产品信息请登录www.canspecsci.com或www.4006087598.com
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